Draft:Joanna Kowalska

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Scientific Contributions

She is fascinated with nucleotides, nucleic acids, oligonucleotides, and other biomolecules. She is most famous for her work with a specific mRNA analog, the 5’ cap, and its use as a reagent for biotechnology and medicine. Due to her work, many new therapeutic applications exist for the strand such as cancer vaccines and treatments for certain genetic diseases. She is also famous for her work with the synthesis and design of similar biomolecules. Her work consists of a wide range of biological methods, including but not limited to, spectroscopy, nuclear magnetic resonance, x-ray crystallography, microscale thermophoresis, and fluorescence microscopy.^[1]^[2]

Biography/Studies

Dr. Joanna Kowalska began her Undergraduate studies from 2002 to 2006 at the College of Interfaculty Individual Studies in Mathematics and Natural Sciences at the University of Warsaw, then got her Bachelor of Science degree in Biotechnology and was in the Faculty of Biology at the University of Warsaw in July 2005. She got her Masters of Science degree in Chemistry - Organic Chemistry and was in the Faculty of Chemistry at the University of Warsaw in June 2006, conducting her undergraduate research in the Division of Biophysics. From 2006-2010 she did her Ph.D. studies in the Division of Biophysics and was in the Faculty of Physics at the University of Warsaw. From 2011 to the present she has been an Adjunct at the Department of Biophysics, Institute of Experimental Physics at Warsaw University in Poland, continuing her work and furthering her studies in medical research.^[3]

Awards^[1]

Finalist of the Magazine "Polityka" competition for young scientists (September 2015)
IS3NA Antonin Holy Poster Award at the International Symposium of Nucleosides, Nucleotides, and Nucleic Acids (Poznań, August 2014)
Individual Second Degree Prize of the Rector of the University of Warsaw for Scientific Achievements 2013
Ministry of Science and Higher Education Scholarship for Young Scientists (2012-2014)
Prof. Stefan Pienkowski Award for Young Scientists (2012).
First prize in the Innovator of Mazovia Competition (2011)
L'Oreal for Women in Science (Polish Edition) prize for pre-doctoral research (2009)
Rector Grzegorz Białkowski Award from Faculty of Physics, University of Warsaw (shared with dr Joanna Żuberek, dr Jacek Jemielity) for "Designing and chemical synthesis of mRNA cap analogues and biophysical studies of their interaction with protein factors" (2008).
Stipend "START" for young researchers from the Foundation for Polish Science (2008 and continuation in 2009)
"Travel Award" for conference abstract on "Joint Symposium of the 18th International Roundtable on Nucleosides, Nucleotides and Nucleic Acids and the 35th Symposium on Nucleic Acids Chemistry", Kyoto, Japan (2008)
Scholarship of Polish Ministry of Science and Higher Education (2004-2005 and 2005-2006)
Best Poster Presentation Award on "XIII Symposium on The Chemistry of Nucleic Acid Components", Spindleruv Mlyn, Czech Republic (2005)

Notable Publications

Przemyslaw Wanat, Sylwia Walczak, Blazej A. Wojtczak, Monika Nowakowska, Jacek Jemielity, and Joanna Kowalska* Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di-and Triphosphates: Synthesis and Reactivity in CuAAC. Org. Lett., 2015, 17 (12), pp 30623065

Marek R Baranowski, Anna Nowicka, Anna M Rydzik, Marcin Warminski, Renata Kasprzyk, Blazej A Wojtczak, Jacek Wojcik, Timothy DW Claridge, Joanna Kowalska,* Jacek Jemielity* Synthesis of Fluorophosphate Nucleotide Analogues and Their Characterization as Tools for 19F NMR Studies J. Org. Chem., 2015, 80 (8),39823997

Monika Zochowska, Anne-Christine Piguet, Jacek Jemielity, Joanna Kowalska, Ewa Szolajska, Jean-François Dufour, Jadwiga Chroboczek*. Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma, Nanomedicine: NBM, 2015, 11, 6776

Joanna Kowalska, Anna Wypijewska del Nogal, Zbigniew M Darzynkiewicz, Janina Buck, Corina Nicola, Andreas N Kuhn, Maciej Lukaszewicz, Joanna Zuberek, Malwina Strenkowska, Marcin Ziemniak, Maciej Maciejczyk, Elzbieta Bojarska, Robert E Rhoads, Edward Darzynkiewicz, Ugur Sahin, Jacek Jemielity* Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes, Nucleic Acids Res. 2014, 42 (16), 10245-10264.

Kowalska J., Lewdorowicz M., Zuberek J., Grudzien-Nogalska E., Bojarska E., Stepinski J., Rhoads R.E., Darzynkiewicz E., Davis R.E., Jemielity J.*; Synthesis and Characterization of mRNA Cap Analogs Containing Phosphorothioate Substitutions that Bind Tightly to eIF4E and are Resistant to the Decapping Pyrophosphatase DcpS. 2008, RNA 14, 1119-1131.

References

^ ^a ^b "Joanna Kowalska - Division of Biophysics". www.biogeo.uw.edu.pl. Retrieved 2024-12-10.
^ "Promotorzy". szkolydoktorskie.uw.edu.pl. Retrieved 2024-12-10.
^ "Dr. Joanna Kowalska". NATURE-ETN. Retrieved 2024-12-10.

Jacek Jemielity, Joanna Kowalska, Edward Darżynkiewicz and team. (n.d.). https://www.epo.org/en/news-events/european-inventor-award/meet-the-finalists/jacek-jemielity-joanna-kowalska-edward

[:0-1] "Joanna Kowalska - Division of Biophysics". www.biogeo.uw.edu.pl. Retrieved 2024-12-10.

[2] "Promotorzy". szkolydoktorskie.uw.edu.pl. Retrieved 2024-12-10.

[3] "Dr. Joanna Kowalska". NATURE-ETN. Retrieved 2024-12-10.

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