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Comment: Besides likely still failing WP:MEDRS, it appears to fail the most basic task of being an article about Kolla2. This is currently a poorly-written article about type II collagen that briefly mentions Kolla2. Snowman304|talk 02:32, 30 October 2024 (UTC)
- Comment: Sources must meet these criteria. bonadea contributions talk 21:37, 12 September 2024 (UTC)
Kolla2 is a dietary supplement derived from avian sternal cartilage, primarily containing Type II collagen, a structural protein found in cartilage. It is investigated for its potential applications in joint health.
Production and Composition
editKolla2 is produced through a patented process.[1]
The final product is a powder that contains up to 65-70% Type II collagen, 20-30% glycosaminoglycans, and 1-3% natural lipids, along with calcium, magnesium, and other essential minerals for bone health.
Composition of Kolla2
edit- Type II Collagen: A type of protein that forms the connective tissues in the body, including skin, bones, and cartilage. Among the different types of collagen, Type II was chosen for its prevalence in joint cartilage (60% of the dry weight of cartilage is Type II collagen[2]) bioavailability, compatibility with human skeletal structures, and its richness in amino acids essential for skeletal connective tissue.
- Hyaluronic acid: A naturally occurring substance found in the body that helps to lubricate joints and maintain skin hydration.
Research and Development
editTerri Lynn Stiles filed for the Kolla2 production patent in 2001 and it was granted in 2004.[3]
The patent proposes the application of Type II Collagen in a number joint tissue concerns including rheumatoid arthritis, Osteoarthritis, cartilage injuries, joint defects, connective tissue disorder, and polychondritis.[1] When looking at recent clinical and scientific research,[4] supplementing with type II collagen might benefit individuals with joint disorders, particularly osteoarthritis. Studies have shown that oral supplementation with undenatured type II collagen can lead to a reduction in joint pain and stiffness by modulating the immune response.[5] The collagen appears to help the body build up tolerance to collagen breakdown products, which are often implicated in the inflammatory processes that exacerbate joint damage. This immune-modulating effect suggests that type II collagen may offer a promising therapeutic approach for managing joint health, particularly in aging populations and those with joint disorders.
Additionally, research has explored the bioavailability[6] and efficacy of type II collagen supplementation.[7] Evidence suggests that undenatured type II collagen possibly works because it maintains its natural structure, which is essential for its interaction with the immune system. Clinical trials have reported that individuals taking undenatured type II collagen experienced significant improvements in joint function on pain relief compared to those taking glucosamine and chondroitin supplements, which are commonly used for joint health.[8] These findings highlight the potential of type II collagen as a targeted therapy for joint health.
Availability and Usage
editType II collagen (kolla2) can be used as a dietary supplement, for therapeutic or preventive purposes, available in forms such as powder, granules, tablets, softgels, or capsules. Various additives used in these oral forms may include one or several of the following: preservatives, sweeteners, flavor enhancers, colorants, and non-toxic, pharmaceutically acceptable excipients such as magnesium stearate, calcium carbonate, sodium carbonate, lactose, etc. Tablets may be uncoated or coated to delay disintegration and absorption in the gastrointestinal tract, providing prolonged action, and may also be enteric-coated. Sustained-release components include mono- and di-glycerides of stearic acid.[3]
References
edit- ^ a b Stiles, Terri Lynn. "Kolla2-desiccated avian sternal cartilage powder". Google Patents. Retrieved 4 September 2024.
- ^ Hernandez, Veronica (2021). "Main and Minor Types of Collagens in the Articular Cartilage: The Role of Collagens in Repair Tissue Evaluation in Chondral Defects". International Journal of Molecular Sciences. 22 (24). National Library of Medicine: 13329. doi:10.3390/ijms222413329. PMC 8706311. PMID 34948124.
- ^ a b Stiles, Terri Lynn. "Patents by Inventor Lynn Stiles". Justia Patents. Retrieved 4 September 2024.
- ^ Martinez-Puig, Daniel (2023). "Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge". Nutrients. 15 (6). National Library of Medicine: 1332. doi:10.3390/nu15061332. PMC 10058045. PMID 36986062.
- ^ Lugo, James (2016). "Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study". Nutrition Journal. 15. National Library of Medicine: 14. doi:10.1186/s12937-016-0130-8. PMC 4731911. PMID 26822714.
- ^ Taga, Yuki (2019). "Improved in Vivo Tracking of Orally Administered Collagen Hydrolysate Using Stable Isotope Labeling and LC-MS Techniques". Journal of Agricultural and Food Chemistry. 67 (16). National Library of Medicine: 4671–4678. doi:10.1021/acs.jafc.9b00571. PMID 30929424. Retrieved 4 September 2024.
- ^ Lugo, James (2016). "Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study". Nutrition Journal. 15. National Library of Medicine: 14. doi:10.1186/s12937-016-0130-8. PMC 4731911. PMID 26822714.
- ^ Kumar, Prasoon (2023). "Efficacy of undenatured collagen in knee osteoarthritis: review of the literature with limited meta-analysis". American Journal of Translational Research. 15 (9). National Library of Medicine: 5545–5555. PMC 10579002. PMID 37854210.