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LUZP2 is a protein-encoding gene that encodes for the leucine zipper protein 2[1].
Gene
editThe LUZP2 gene is found on the short arm of chromosome 11 at position 11p14.3[2]. It is located on the plus strand[2]. Aliases for the protein include UNQ2566/PRO6246, PRO6246, FLJ45795 or KFSP2566, LOC338645[3].
The gene contains 23 introns, and can produce 11 alternatively spliced mRNAs[3].
Protein
editLUZP2 encodes a leucine zipper protein that is 346 amino acids in length, and has a molecular weight of around 39 kDa[4]. This protein is secreted, and is found mostly expressed within the brain and spinal cord[1].
The protein contains a signal peptide, 3 glycosylation sites, 2 leucine zipper regions, and a disordered region[4].
Clinical findings
editBased on a data mining study investigating low-grade Gliomas, LUZP2 downregulation was found to be associated with higher-grade tumors, suggesting that LUZP2 expression decreased as tumors became more aggressive. Low LUZP2 expression was also associated with worse overall survival in patients with Low grade gliomas across multiple cohorts[5].
This gene has also been found deleted in some patients with Wilms tumor-aniridia-ganomalies-mental retardation (WAGR) syndrome[6].
Evolution
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LUZP2 has no known paralogs, but has many orthologs in vertebrates. It is highly conserved in mammals, birds, and reptiles[7].
LUZP2 is expected to have first appeared in cartilaginous fish around 462 million years ago, and is evolving at an intermediate rate, slower than fibrinogen alpha, but faster than cytochrome c.
References
edit- ^ a b "UniProt". www.uniprot.org. Retrieved 2024-10-12.
- ^ a b "Homo sapiens leucine zipper protein 2 (LUZP2), transcript variant 1, mRNA". National Library of Medicine. 2024-06-08.
- ^ a b "AceView: Gene:LUZP2, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2024-10-12.
- ^ a b "leucine zipper protein 2 isoform 1 precursor [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-10-12.
- ^ Li, Yong; Deng, Gang; Qi, Yangzhi; Zhang, Huikai; Jiang, Hongxiang; Geng, Rongxin; Ye, Zhang; Liu, Baohui; Chen, Qianxue (2020-07-10). "Downregulation of LUZP2 Is Correlated with Poor Prognosis of Low-Grade Glioma". BioMed Research International. 2020: 1–16. doi:10.1155/2020/9716720. ISSN 2314-6133. PMC 7368956. PMID 32695826.
- ^ Wu, Min; Michaud, Edward J.; Johnson, Dabney K. (2003-05-01). "Cloning, functional study and comparative mapping of Luzp2 to mouse Chromosome 7 and human Chromosome 11p13–11p14". Mammalian Genome. 14 (5): 323–334. doi:10.1007/s00335-002-2248-6. ISSN 1432-1777. PMID 12856284.
- ^ "LUZP2 orthologs". NCBI. Retrieved 2024-10-13.