Draft:Professor Rajesh Dabur

Dr Rajesh Dabur born in a small village namely, Changroad, located in district Charkhi Dadri, Haryana in 1971.

References

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1.      Yadav A, Dabur R. Skeletal muscle atrophy after sciatic nerve damage: Mechanistic insights. European Journal of Pharmacology. 2024 Mar 15:176506.

2.      Yadav, A. and Dabur, R.,. Ursolic acid restores redox homeostasis and proinflammatory cytokines production in denervation-induced skeletal muscle atrophy. Appl Biochem Biotechnol, 2024, In pressApplied Biochemistry and Biotechnology

3.      Yadav A, Yadav SS, Singh S, Dabur R. Natural products: Potential therapeutic agents to prevent skeletal muscle atrophy. Eur J Pharmacol. 2022 Jun 15;925:174995. doi: 10.1016/j.ejphar.2022.174995. Epub 2022 May 9. PMID: 35523319.

4.      Yadav A, Shirolkar A, Dabur R. Impact of Ayurvedic drug Tinospora cordifolia in hyperlipidemia induced dysbiosis. Chemical Biology Letters. 2022 Apr 24;9(3):363-.

5.      Yadav A, Dabur R. Rapid Identification of 44 Steroids in Human Urine Samples using HPLCESI-QTOF-MS. Current Pharmaceutical Analysis. 2022 May 1;18(4):437-48.

6.      Yadav A, Yadav S, Dabur R. Higher plants exert interspecific effects on the phytoecdysteroids contents in Tinospora cordifolia. Chemical Biology Letters. 2022 Feb 1;9(1):312-.

7.      Shirolkar A, Yadav A, Nale A, Phogat J, Dabur R. Integrated omics analysis revealed the Tinospora cordifolia intervention modulated multiple signaling pathways in hypertriglyceridemia patients-a pilot clinical trial. J Diabetes Metab Disord. 2022 Feb 1;21(1):379-397. doi: 10.1007/s40200-022-00985-6. PMID: 35673460; PMCID: PMC9167413.

8.      Singh A, Yadav A, Phogat J, Dabur R. Dynamics and Interplay between Autophagy and Ubiquitin-proteasome system Coordination in Skeletal Muscle Atrophy. Curr Mol Pharmacol. 2022;15(3):475-486. doi: 10.2174/1874467214666210806163851. PMID: 34365963.

9.      Singh A, Phogat J, Yadav A, Dabur R. The dependency of autophagy and ubiquitin proteasome system during skeletal muscle atrophy. Biophys Rev. 2021 Mar 4;13(2):203-219. doi: 10.1007/s12551-021-00789-7. PMID: 33927785; PMCID: PMC8046863.

10.   Yadav A, Singh A, Phogat J, Dahuja A, Dabur R. Magnoflorine prevent the skeletal muscle atrophy via Akt/mTOR/FoxO signal pathway and increase slow-MyHC production in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2021 Mar 1;267:113510. doi: 10.1016/j.jep.2020.113510. Epub 2020 Oct 24. PMID: 33141056.

11.   Yadav A, Dahuja A, Dabur R. Dynamics of Toll-like Receptors Signaling in Skeletal Muscle Atrophy. Curr Med Chem. 2021;28(28):5831-5846. doi: 10.2174/0929867328666210202113734. PMID: 33530901.

12.   Shirolkar A, Yadav A, Mandal TK, Dabur R. Intervention of Ayurvedic drug Tinospora cordifolia attenuates the metabolic alterations in hypertriglyceridemia: a pilot clinical trial. J Diabetes Metab Disord. 2020 Oct 16;19(2):1367-1379. doi: 10.1007/s40200-020-00657-3. PMID: 33520840; PMCID: PMC7843799.

13.   Gupta P, Dutt V, Kaur N, Kalra P, Gupta S, Dua A, Dabur R, Saini V, Mittal A. S-allyl cysteine: A potential compound against skeletal muscle atrophy. Biochim Biophys Acta Gen Subj. 2020 Oct;1864(10):129676. doi: 10.1016/j.bbagen.2020.129676. Epub 2020 Jul 7. PMID: 32649980.

14.   Sharma B, Dutt V, Kaur N, Mittal A, Dabur R. Tinospora cordifolia protects from skeletal muscle atrophy by alleviating oxidative stress and inflammation induced by sciatic denervation. J Ethnopharmacol. 2020 May 23;254:112720. doi: 10.1016/j.jep.2020.112720. Epub 2020 Feb 27. PMID: 32114167.

15.   Sharma B, Dabur R. Role of Pro-inflammatory Cytokines in Regulation of Skeletal Muscle Metabolism: A Systematic Review. Curr Med Chem. 2020;27(13):2161-2188. doi: 10.2174/0929867326666181129095309. PMID: 30488792.

16.   Sharma B, Yadav A, Dabur R. Interactions of a medicinal climber Tinospora cordifolia with supportive interspecific plants trigger the modulation in its secondary metabolic profiles. Sci Rep. 2019 Oct 4;9(1):14327. doi: 10.1038/s41598-019-50801-0. PMID: 31586109; PMCID: PMC6778175.

17.   Soni M, Prakash C, Dabur R, Kumar V. Protective Effect of Hydroxytyrosol Against Oxidative Stress Mediated by Arsenic-Induced Neurotoxicity in Rats. Appl Biochem Biotechnol. 2018 Sep;186(1):27-39. doi: 10.1007/s12010-018-2723-5. Epub 2018 Mar 2. PMID: 29497947.

18.   Bhosale JD, Dabur R, Jadhav GP, Bendre RS. Facile Syntheses and Molecular-Docking of Novel Substituted 3,4-Dimethyl-1H-pyrrole-2-carboxamide/carbohydrazide Analogues with Antimicrobial and Antifungal Properties. Molecules. 2018 Apr 11;23(4):875. doi: 10.3390/molecules23040875. PMID: 29641457; PMCID: PMC6017109.

19.   Shirolkar A, Chakraborty S, Mandal T, Dabur R. Plasma metabolomics reveal the correlation of metabolic pathways and Prakritis of humans. J Ayurveda Integr Med. 2018 Apr-Jun;9(2):113-122. doi: 10.1016/j.jaim.2017.05.002. Epub 2017 Nov 26. PMID: 29183656; PMCID: PMC6033735.

20.   Jain P, Nale A, Dabur R. Antimicrobial metabolites from Saraca asoca impairs the membrane transport system and quorum-sensing system in Pseudomonas aeruginosa. Arch Microbiol. 2018 Mar;200(2):237-253. doi: 10.1007/s00203-017-1435-5. Epub 2017 Oct 9. PMID: 28993916.

21.   Dabur R, Shirolkar A, Mishra V, Yadav BS. Non-invasive Qualitative Urinary Metabolomic Profiling Discriminates Gut Microbiota Derived Metabolites in the Moderate and Chronic Alcoholic Cohorts. Curr Pharm Biotechnol. 2017;18(14):1175-1189. doi: 10.2174/1389201019666180308093207. PMID: 29521221.

22.   Rajesh Dabur. Identification of molecular pathways affected by treatment with heartwood water extract of Pterocarpus marsupium in MCF 7 cancer cell line. Herbal Medicine. Volume 9, September 2017, Pages 42-52 http://doi.org/10.1016/j.hermed.2017.04.001.

23. Gupta, P., Bala, M., Gupta, S., Dua, A.a, Dabur, R.b,, Injeti, E., Mittal, A. Efficacy and risk profile of anti-diabetic therapies: Conventional vs traditional drugs—A mechanistic revisit to understand their mode of action. 2016, Pharmacological Research, 113, pp. 636-674

24. Amey Shirolkar, Rajesh Dabur. Administration of Fresh Juice of Tinospora cordifolia Decreases Levels of Urinary Markers of Peroxisome Proliferator-Activated Receptors in Hyperlipidemic Patients. Ind J Pharma Edu Res. 2016, 50,

25. Amey Shirolkar, Bhawana Sharma, Suman Lata, Rajesh Dabur. Guduchi Sawras (Tinospora cordifolia): An Ayurvedic drug treatment modulates the impaired lipid metabolism in alcoholics through dopaminergic neurotransmission and anti-oxidant defense system. Biomedicine & Pharmacotherapy. 2016. 83, 1265–1277.

26. Phougat, N., Chhillar, A.K.,Prasad, A.K., Srivastava, S.,Dabur, R. Coumarin derivatives as adjuvants: From in silico physicochemical characterization to in vitro evaluation against gram positive bacteria 2016.   Combinatorial Chemistry and High Throughput Screening 19 (6), pp. 489-496

27. Dabur, R., Mittal, A. Detection and qualitative analysis of fatty acid amides in the urine of alcoholics using HPLC-QTOF-MS. 2016  Alcohol 52, pp. 71-78

28. Bhosale, Jitendra, Umesh Fegade, Banashree Bondhopadhyay, Simanpreet Kaur, Narinder Singh, Anupam Basu, Rajesh Dabur, Ratnamala Bendre, and Anil Kuwar. "Pyrrole‐coupled salicylimine‐based fluorescence “turn on” probe for highly selective recognition of Zn2+ ions in mixed aqueous media: Application in living cell imaging." Journal of Molecular Recognition (2015), 28(6):369-75.  doi: 10.1002/jmr.2451.

29. Dutt Vikas, Gupta Snjeev, Dabur Rajesh, Injeti Elisha and Mittal Ashwani. Skeletal muscle atrophy: Potential therapeutic agents and their mechanisms of action. Pharmacological Research (2015), 99:  86–100.

30. Kumari, Suman, Preeti Jain, Bhawana Sharma, Preeti Kadyan, and Rajesh Dabur. "In Vitro Antifungal Activity and Probable Fungicidal Mechanism of Aqueous Extract of Barleria Grandiflora." Applied Biochemistry and Biotechnology (2015): 1-14. DOI: 10.1007/s12010-015-1527-0

31. Mittal, Ashwani, and Rajesh Dabur. Detection of New Human Metabolic Urinary Markers in Chronic Alcoholism and Their Reversal by Aqueous Extract of Tinospora cordifolia Stem. Alcohol and Alcoholism (2015): agv012.

32. Sharma, B., Dabur, R. Protective effects of Tinospora cordifolia on hepatic and gastrointestinal toxicity induced by chronic and moderate alcoholism. 2015 Alcohol and Alcoholism51 (1), agv130, pp. 1-10.

33. Gahlaut, A., Dabur, R. Proteomic analysis of Escherichia coli in response to catechins rich fraction (2014) International Journal of Pharmacy and Pharmaceutical Sciences, 6 (1), pp. 784-787.

34. Phougat, N., Khatri, S., Singh, A., Dangi, M., Kumar, M., Dabur, R., Chhillar, A.K. Combination therapy: The propitious rationale for drug development (2014) Combinatorial Chemistry and High Throughput Screening, 17 (1), pp. 53-67.

35. Singh, Seema, Rajesh Dabur, Madhumanjiri M. Gatne, Bharat Singh, Shilpi Gupta, Sharad Pawar, Sunil K. Sharma, and Gainda L. Sharma. "In Vivo Efficacy of a Synthetic Coumarin Derivative in a Murine Model of Aspergillosis." PloS one 9, no. 8 (2014): e103039. 

36. Mittal, A., Kadyan, P., Gahlaut, A., Dabur, R. Nontargeted identification of the phenolic and other compounds of Saraca asoca by high performance liquid chromatography-positive electrospray ionization and quadrupole time-of-flight mass spectrometry . ISRN Pharm. 2013 pp. 11.

37. Bhosale, J.D., Shirolkar, A.R., Pete, U.D., Zade, C.M., Mahajan, D.P., Hadole, C.D., Pawar, S.D., Patil, U.D., Dabur, R., Bendre, R.S. Synthesis, characterization and biological activities of novel substituted formazans of 3,4-dimethyl-1Hpyrrole-2-carbohydrazide derivatives (2013) Journal of Pharmacy Research, 7 (7), pp. 582-587.

38. Gahlaut, A., Dabur, R., Chhillar, A.K. Anti-Aspergillus activity of selected medicinal plants (2013) Journal of Pharmacy Research, 6 (4), pp. 419-422.

39. Gahlaut, A., Gothwal, A., Hooda, V., Dabur, R. RAPD patterns of some important medicinal plants and their substitutes used in Ayurveda to identify the genetic variations (2013) International Journal of Pharmacy and Pharmaceutical Sciences, 5 (1), pp. 239-241.

40. Gahlaut, A., Sharma, A., Shirolkar, A., Dabur, R. Non-targeted identification of compounds from regenerated bark of terminalia tomentosa by HPLC- (+) ESI-QTOFMS (2013) Journal of Pharmacy Research, 6 (4), pp. 415-418.

41. Gahlaut, A., Shirolkar, A., Hooda, V., Dabur, R. A rapid and simple approach to discriminate various extracts of saraca asoca [Roxb.], De. Wild using UPLC-QTOFMS and multivariate analysis (2013) Journal of Pharmacy Research,7 (2), pp. 143-149. Cited 5 times.

42. Gahlaut, A., Shirolkar, A., Hooda, V., Dabur, R. β-Sitosterol in different parts of Saraca asoca and herbal drug ashokarista: Quali-quantitative analysis by liquid chromatography-mass spectrometry (2013) Journal of Advanced Pharmaceutical Technology and Research, 4 (3), pp. 146-150.

43. Gahlaut, A., Vikas, Dahiya, M., Gothwal, A., Kulharia, M., Chhillar, A.K., Hooda, V., Dabur, R. Proteomics & metabolomics: Mapping biochemical regulations (2013) Drug Invention Today, 5 (4), pp. 321-326.

44. Mittal, A., Gahlaut, A., Sharma, G.L., Dabur, R. Antifungal treatments delineate a correlation between cathepsins and cytokines in murine model of invasive aspergillosis (2013) Indian Journal of Pharmaceutical Sciences, 75 (6), pp. 688-699.

45. Shirolkar, A., Gahlaut, A., Chhillar, A.K., Dabur, R. Quantitative analysis of catechins in Saraca asoca and correlation with antimicrobial activity (2013) Journal of Pharmaceutical Analysis, 3 (6), pp. 421-428.

46. Shirolkar, A., Gahlaut, A., Hooda, V., Dabur, R. Phytochemical composition changes in untreated stem juice of tinospora cordifolia (W) Mier during refrigerated storage (2013) Journal of Pharmacy Research, 7 (1), pp. 1-6.

47. Gahlaut, A., Gothwal, A., Dabur, R. TLC based analysis of allelopathic effects on tinosporoside contents in Tinospora cordifolia (2012) Journal of Chemical and Pharmaceutical Research, 4 (6), pp. 3082-3088. Cited 6 times.

48. Gahlaut, A., Pawar, S.D., Mandal, T.K., Dabur, R. Biochemical analysis of lithiasis patients and treatment study using Bryophyllum pinnatum salisb (2012) International Journal of Pharmacy and Pharmaceutical Sciences, 4 (4), pp. 505-507.

49. Gahlaut, A., Taneja, P., Shirolkar, A., Nale, A., Hooda, V., Dabur, R. Principal component and partial least square discriminant based analysis of methanol extracts of bark and re-generated bark of Saraca Asoca(2012) International Journal of Pharmacy and Pharmaceutical Sciences, 4 (4), pp. 331-335.

50. Mittal, A., Mandal, T.K., Bindal, R., Dabur, R Cathepsin B is a negative regulator in pulmonary aspergillosis Int J Biosci Biochem Bioinforma 2011. 1, pp. 125-130

51. Bhosale, J.D., Khond, M., Mandal, T.K., Bendre, R.S., Dabur, R. Identification and characterization of two novel antimicrobial compounds from jasminum grandiflorum L. (2011) World Applied Sciences Journal, 13 (1), pp. 47-51. 

52. Dabur R, Mandal TK, Gurav AM, Tasleem Arif, Singh DD. Bajpai V, Chandra K. (2009). Antibacterial and Antifungal Potential of two Blumea species used in folkloric medicine. Journal of Drug Research in Ayurveda and Siddha. Vol: XXX (3-4), 77-82.

53. Mangesh Khond, J.D. Bhosale, Tasleem Arif, T.K. Mandal, M.M. Padhi and Rajesh Dabur. Screening of Some Selected Medicinal Plants Extracts for In-vitro Antimicrobial Activity. Middle-East Journal of Scientific Research 4 (4): 271-278, 2009.

54. Rajesh Dabur, J. D. Bhosale, Mangesh Khond, TK Mandal, MM Padhi. Identification and characterization of two new antimicrobial compounds from Jasminum grandiflorum. Middle-East Journal of Scientific Research. 2009. 4 (4), pp. 271-278.

55. Tasleem Arif, JD Bhosale, Naresh Kumar, TK Mandal, RS Bendre, GS Lavekar, Rajesh Dabur, (2009). Natural Products- Anti-Fungal Agents Derived from Plants. Asian Journal of Natural Product and Research. Journal of Asian Natural Products Research. Vol. 11 (7), 621-638.

56. Tasleem Arif, T.K. Mandal, Naresh Kumar, J.D. Bhosale, Archana Hole, G.L. Sharma, M.M. Padhi, G.S. Lavekar, Rajesh Dabur, (2009). In vitro and in vivo antimicrobial activities of seeds of Caesalpinia bonduc (Lin.) Roxb. Journal of Ethanopharmacology 123, 177–180.

57. Piyush Bihari Lal, Naresh Kumar, Tasleem Arif, Akhilesh K. Verma, Sharma GL, Rajesh Dabur. (2008). In vitro anti-bacterial activity of a novel isoquinoline derivative and its post antibacterial effects on Pseudomonas aeruginosa. African Journal of Microbiology. 2: 126-130.

58. Dabur R, Mandal TK, Gurav AM, Singh DD. Bajpai V, GS Lavekar. (2007). Antibacterial and Antifungal Potential of some Indian medicinal plants Afr J Trad CAM. 4(3):319-322.

59. Dabur R, Mandal TK, Sharma GL (2007). Post antifungal effects of antifungal compound 2-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1-methylethyl pentanoate. J Med Microbiol. 56: 815-818.

60. Gupta, J; Chattopadhaya, D; Bhadoria, D P; Pasha, MAQ; Gupta, Vijay; Kumar, M; Dabur, R; Yadav, V; Sharma, GL (2007). T-lymphocyte subset profile and serum alpha-1-antitrypsin in pathogenesis of chronic obstructive pulmonary disease. Clinical and Experimental Immunology. 149(3):463-9.

61. V. Yadav, R Mandhan, Q Pasha, S. Pasha, A Katyal, AK Chhillar, J Gupta, R Dabur and GL Sharma (2007). Isolation and characterization of an antifungal protein from Escherichia coli. J. Med Microbiol. 56: 637-644.

62. Chhillar AK, Arya P, Mukherjee C, Kumar P, Yadav Y, Sharma AK, Yadav V,Gupta J, Dabur R, Jha HN, Watterson AC, Parmar VS, Prasad AK, Sharma GL.  Microwave-assisted synthesis of antimicrobial dihydropyridines and tetrahydropyrimidin-2-ones: novel compounds against aspergillosis. Bioorg Med Chem. 2006 Feb 15; 14(4):973-81. Epub 2005 Oct 7. PMID: 16214352 [PubMed - indexed for MEDLINE].

63. Tiwari RK, Singh D, Singh J, Yadav V, Pathak AK, Dabur R, Chhillar AK, Singh R, Sharma GL, Chandra R, Verma AK. Synthesis and antibacterial activity of substituted 1,2,3,4-tetrahydropyrazino[1,2-a] indoles. Bioorg Med Chem Lett. 2006 Jan 15; 16(2):413-6. Epub 2005 Oct 21. PMID: 16246547 [PubMed - indexed for MEDLINE].

64. Ashok K. Prasad, Vineet Kumar, Pragya Arya, Sarvesh Kumar, Rajesh Dabur,  Naresh Singh, Anil K. Chhillar, Gainda L. Sharma, Balaram Ghosh, Jesper Wengel, Carl E. Olsen, and Virinder S. Parmar. Investigations toward new lead compounds from medicinally important plants. Pure Appl. Chem. 77(1), 25-40, 2005. DOI: 10.1351/pac200577010025.

65. Clark J, Shevchuk T, Swiderski PM, Dabur R, Crocitto LE, Buryanov YI, Smith SS.  Construction of ordered protein arrays. Methods Mol Biol. 2005; 300:325-48. Review. PMID: 15657490 [PubMed - indexed for MEDLINE].

66. Dabur R, Chhillar AK, Yadav V, Kamal PK, Gupta J, Sharma GL. In vitro antifungal activity of 2-(3,4-dimethyl-2,5-dihydro-1H-pyrrol-2-yl)-1-methylethyl pentanoate, a dihydropyrrole derivative. J Med Microbiol. 2005 Jun; 54(Pt 6):549-52. PMID: 15888463 [PubMed - indexed for MEDLINE].

67. Dabur R, Diwedi SK, Yadav V, Mishra V, Singh R, Singh H, Sharma GL. Efficacy of 2-(3,4-dimethyl-2,5-dihydro-1h-pyrrole-2-yl)-1-methylethylpentanoate in a murine model of invasive aspergillosis. Antimicrob Agents Chemother. 2005 Oct; 49(10):4365-7. PMID: 16189123 [PubMed - indexed for MEDLINE]

68. Gupta J, Bhadoria DP, Lal MK, Kukreti R, Chattopadhaya D, Gupta VK, Dabur R, Yadav V, Chhillar AK, Sharma GL. Association of the PIM3 allele of the alpha-1-antitrypsin gene with chronic obstructive pulmonary disease. Clin Biochem. 2005 May; 38(5):489-91. PMID: 15820782 [PubMed - indexed for MEDLINE]

69. Sawaya MR, Zhu Z, Mersha F, Chan SH, Dabur R, Xu SY, Balendiran GK. Crystal structure of the restriction-modification system control element C.Bclland mapping of its binding site. Structure. 2005 Dec; 13(12):1837-47. PMID: 16338412 [PubMed - indexed for MEDLINE]

70. Yadav V, Gupta J, Mandhan R, Chhillar AK, Dabur R, Singh DD, Sharma GL. Investigations on anti-Aspergillus properties of bacterial products. Lett Appl Microbiol. 2005; 41(4):309-14. PMID: 16162136 [PubMed - indexed for MEDLINE]

71. Yadav V, Mandhan R, Dabur R, Chhillar AK, Gupta J, Sharma GL. A fraction from Escherichia coli with anti-Aspergillus properties. J Med Microbiol. 2005 Apr; 54(Pt 4):375-9. PMID: 15770023 [PubMed - indexed for MEDLINE]

72. Dabur R, Ali M, Singh H, Gupta J, Sharma GL. A novel antifungal pyrrole derivative from Datura metel leaves. Pharmazie. 2004 Jul; 59(7):568-70. PMID: 15296098 [PubMed - indexed for MEDLINE]

73. A.K. Ashok, V. Kumar, P. Arya, S. Kumar, R. Dabur, N. Singh, A.K. Chhillar, G.L. Sharma, B. Ghosh, J. Wengel , C.E. Olsen and V.S. Parmar: Investigations towards new lead compounds from medicinally important plants. In Proceedings of bioresources towards drug discovery and development (2004), p. 213-235, ISBN No: 99903-73-16-7.

74. Balendiran GK, Dabur R, Fraser D. The role of glutathione in cancer. Cell Biochem Funct. 2004 Nov-Dec; 22(6):343-52. Review. PMID: 15386533 [PubMed - indexed for MEDLINE]

75. Clark J, Shevchuk T, Swiderski PM, Dabur R, Crocitto LE, Buryanov YI, Smith SS.  Mobility-shift analysis with microfluidics chips. Biotechniques. 2003 Sep; 35(3):548-54. PMID: 14513560 [PubMed - indexed for MEDLINE]

76. Dabur R, Singh H, Chhillar AK, Ali M, Sharma GL. Antifungal potential of Indian medicinal plants. Fitoterapia. 2003 Jun; 75(3-4):389-91. PMID: 15159003 [PubMed - indexed for MEDLINE]

77. Rajesh and Sharma G L (2002). Studies on antimycotic properties of Datura metel. J Ethanopharmacol (80) 193-197. [PubMed - indexed for MEDLINE]