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Comment: Please cut down the list of 'Published works' significantly – Wikipedia is not intended as a comprehensive catalogue of someone's entire output; focus on the most notable ones only (I'd say ideally fewer than ten). DoubleGrazing (talk) 12:55, 26 July 2024 (UTC)
Todd O. Yeates | |
|---|---|
| Born | 1961 |
| Occupation(s) | American biophysicist and structural biologist |
Todd Owen Yeates (1961 –) Todd Yeates was a Professor at the University of California Los Angeles, from 1990 to 2024. In 2001 his research laboratory invented the field of designed protein cages [1][2][3][4] Designed protein cages are engineered molecular nanoparticles that self-assemble into geometric shapes reminiscent of the Platonic solids (e.g. a cube, tetrahedron, or icosahedron). They have found diverse applications in medicine and biotechnology. Beginning in 2005, his research laboratory elucidated the three-dimensional structures of bacterial microcompartments (known as BMCs or MCPs) [5][6][7][8][9]. Bacterial microcompartments assemble from thousands of hexagonal and pentagonal protein components to form a shell, reminiscent of a large viral capsid, with enzymes encapsulated in the interior and selective pores in the shell that allow passage of enzyme substrates and products. Bacterial microcompartments modify the textbook view of cell biology by highlighting an alternative type of metabolic organelle, one based on a protein shell rather than a lipid membrane, the latter being a defining feature of organelles found in eukaryotic (plant and animal) cells. Yeates’ research led to methodological advances in X-ray crystallography[10][11] and cryo-electron microscopy[12]. From 2019 to 2023 he served as the Director of the US Department of Energy Institute for Genomics and Proteomics.
References/Notes and references
edit- ^ Padilla JE, Colovos C, Yeates TO. Nanohedra: using symmetry to design self assembling protein cages, layers, crystals, and filaments. Proc Natl Acad Sci USA. 2001 Feb 27;98(5):2217-21. doi: 10.1073/pnas.041614998.
- ^ Yeates TO, Padilla JE. Designing supramolecular protein assemblies. Curr Opin Struct Biol. 2002 Aug;12(4):464-70. doi: 10.1016/s0959-440x(02)00350-0
- ^ Lai YT, Cascio D, Yeates TO. Structure of a 16-nm cage designed by using protein oligomers. Science. 2012 Jun 1;336(6085):1129. doi:10.1126/science.1219351.
- ^ Yeates TO. Geometric Principles for Designing Highly Symmetric Self-Assembling Protein Nanomaterials. Annu Rev Biophys. 2017 May 22;46:23-42. doi:10.1146/annurev-biophys-070816-033928. .
- ^ Yeates TO, Kerfeld CA, Heinhorst S, Cannon GC, Shively JM. Protein-based organelles in bacteria: carboxysomes and related microcompartments. Nat Rev Microbiol. 2008 Sep;6(9):681-91. doi: 10.1038/nrmicro1913
- ^ Kerfeld CA, Sawaya MR, Tanaka S, Nguyen CV, Phillips M, Beeby M, Yeates TO. Protein structures forming the shell of primitive bacterial organelles. Science. 2005 Aug 5;309(5736):936-8. doi: 10.1126/science.1113397.
- ^ Tsai Y, Sawaya MR, Cannon GC, Cai F, Williams EB, Heinhorst S, Kerfeld CA, Yeates TO. Structural analysis of CsoS1A and the protein shell of the Halothiobacillus neapolitanus carboxysome. PLoS Biol. 2007 Jun;5(6):e144. doi:10.1371/journal.pbio.0050144.
- ^ Tanaka S, Kerfeld CA, Sawaya MR, Cai F, Heinhorst S, Cannon GC, Yeates TO. Atomic-level models of the bacterial carboxysome shell. Science. 2008 Feb 22;319(5866):1083-6. doi: 10.1126/science.1151458.
- ^ Tanaka S, Sawaya MR, Yeates TO. Structure and mechanisms of a protein-based organelle in Escherichia coli. Science. 2010 Jan 1;327(5961):81-4. doi:10.1126/science.1179513
- ^ Padilla JE, Yeates TO. A statistic for local intensity differences: robustness to anisotropy and pseudo-centering and utility for detecting twinning. Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1124-30. doi:10.1107/s0907444903007947
- ^ Yeates TO, Kent SB. Racemic protein crystallography. Annu Rev Biophys. 2012;41:41-61. doi: 10.1146/annurev-biophys-050511-102333
- ^ Castells-Graells R, Meador K, Arbing MA, Sawaya MR, Gee M, Cascio D, Gleave E, Debreczeni JÉ, Breed J, Leopold K, Patel A, Jahagirdar D, Lyons B, Subramaniam S, Phillips C, Yeates TO. Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold. Proc Natl Acad Sci U S A. 2023 Sep 12;120(37):e2305494120. doi:10.1073/pnas.2305494120.