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Unalamation (pronounced: un-ala-mation).[1] describes homeostatic physiology where the so called 'inflammatory' lipid mediators maintain normal homeostatic physiological functions under the influence of anti-inflammatory lipid mediators. When there is injury, physical or microbial, acute inflammation is triggered by the biosynthesis of inflammatory lipid mediators such as prostaglandins and leukotrienes[2]. Levels of these inflammatory mediators descend to normal tissue concentrations as the acute inflammation is resolved. In certain tissues such as kidneys, heart, brain, intestines, and during physiological changes such as ovulation and parturition[3], these 'inflammatory' lipid mediators are present at high concentrations or increased during the physiological change[4]. Yet, there are no signs of inflammation. It is the simultaneous presence of anti-inflammatory lipid mediators such as epoxy polyunsaturated fatty acids that regulate the inflammatory propensity of prostaglandins towards homeostasis and this is designated as unalamation[5][6]
References
edit- ^ Maddipati, Krishna Rao (7 October 2020). "Non-inflammatory Physiology of "Inflammatory" Mediators – Unalamation, a New Paradigm". Frontiers in Immunology. 11. doi:10.3389/fimmu.2020.580117. PMC 7575772. PMID 33117385.
- ^ Ricciotti, Emanuela; FitzGerald, Garret A. (May 2011). "Prostaglandins and Inflammation". Arteriosclerosis, Thrombosis, and Vascular Biology. 31 (5): 986–1000. doi:10.1161/ATVBAHA.110.207449. PMC 3081099. PMID 21508345.
- ^ Li, Wen-jiao; Lu, Jiang-wen; Zhang, Chu-yue; Wang, Wang-sheng; Ying, Hao; Myatt, Leslie; Sun, Kang (January 2021). "PGE2 vs PGF2α in human parturition". Placenta. 104: 208–219. doi:10.1016/j.placenta.2020.12.012. PMID 33429118.
- ^ Duffy, Diane M; Ko, CheMyong; Jo, Misung; Brannstrom, Mats; Curry, Thomas E (1 April 2019). "Ovulation: Parallels With Inflammatory Processes". Endocrine Reviews. 40 (2): 369–416. doi:10.1210/er.2018-00075. PMC 6405411. PMID 30496379.
- ^ Wautier, Jean-Luc; Wautier, Marie-Paule (1 June 2023). "Pro- and Anti-Inflammatory Prostaglandins and Cytokines in Humans: A Mini Review". International Journal of Molecular Sciences. 24 (11): 9647. doi:10.3390/ijms24119647. PMC 10253712. PMID 37298597.
- ^ Aradhyula, Vaishnavi; Waigi, Emily; Bearss, Nicole R.; Edwards, Jonnelle M.; Joe, Bina; McCarthy, Cameron G.; Koch, Lauren B.; Wenceslau, Camilla F. (October 2021). "Intrinsic exercise capacity induces divergent vascular plasticity via arachidonic acid-mediated inflammatory pathways in female rats". Vascular Pharmacology. 140: 106862. doi:10.1016/j.vph.2021.106862. PMC 8448916. PMID 33872803.