The drum RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] Drum motifs are found in Bacillota, Bacteroidota, Pseudomonadota, and Spirochaetota, and exhibit multiple highly conserved nucleotide positions, despite their widespread distribution.[1]
| drum | |
|---|---|
 Consensus secondary structure and sequence conservation of drum RNA | |
| Identifiers | |
| Symbol | drum |
| Rfam | RF02958 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | SO:0001263 |
| PDB structures | PDBe |
Drum RNAs likely function in trans as small RNAs, and are often immediately followed on their 3′ ends by Rho-independent transcription terminators. Genes that encode apparently homologous proteins are often located nearby to drum RNAs. These genes can occur 5′ or 3′ relative to the RNA, and on the same or opposite DNA strand. Occasionally, these proteins match the DUF3800 conserved protein domain,[1] and so drum RNAs might be an example of DUF3800 RNA motifs.
Drum RNAs contain a predicted kink turn.[2] This particular example of a kink turn was studied to better understand how kink turn structures relate to their sequences.
References
edit- ^ a b c Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.
- ^ Huang L, Liao X, Li M, Wang J, Peng X, Wilson TJ, Lilley DM (June 2021). "Structure and folding of four putative kink turns identified in structured RNA species in a test of structural prediction rules". Nucleic Acids Res. 49 (10): 5916–5924. doi:10.1093/nar/gkab333. PMC 8191799. PMID 33978763.