Duke George may refer to:
- Grand Duke George of Russia (disambiguation), multiple people
- George, Duke of Saxony, 1471–1539
- Duke George Augustus of Mecklenburg, 1748–1785
- Duke George of Oldenburg, 1471–1539
- Georg Alexander, Duke of Mecklenburg, 1899–1963
- Georg II, Duke of Saxe-Meiningen 1826–1914