Dynein axonemal light chain 1

DNAL1
Identifiers
Aliases	DNAL1, C14orf168, CILD16, dynein axonemal light chain 1, LC1
External IDs	OMIM: 610062; MGI: 1921462; HomoloGene: 34623; GeneCards: DNAL1; OMA:DNAL1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	73,703,732 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	84,194,272 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; left testis; ; right testis; ; bronchial epithelial cell; ; mucosa of paranasal sinus; ; Achilles tendon; ; corpus callosum; ; caput epididymis; ; islet of Langerhans; ; internal globus pallidus;
	Top expressed in
	otolith organ; ; utricle; ; Region I of hippocampus proper; ; nucleus accumbens; ; temporal lobe; ; lateral septal nucleus; ; amygdala; ; dorsal striatum; ; piriform cortex; ; prefrontal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	alpha-tubulin binding; dynein heavy chain binding; cytoskeletal motor activity; protein binding;
Cellular component	outer dynein arm; cytoplasm; cytoskeleton; microtubule; dynein complex; cell projection;
Biological process	outer dynein arm assembly;
	Sources:Amigo / QuickGO
Orthologs
	83544
	105000
	ENSG00000119661
	ENSMUSG00000042523
	Q4LDG9
	Q05A62
	NM_001201366; NM_031427
	NM_028821; NM_001346528
	NP_001188295; NP_113615
	NP_001333457; NP_083097
	Wikidata
View/Edit Human	View/Edit Mouse

Dynein axonemal light chain 1, (LC1) is a protein that in humans is encoded by the DNAL1 gene.^[5]^[6]

Function

LC1 is a component of outer dynein arms, which contain the molecular motors for ATP-dependent cilia movement.^[5]^[6]

Mutations in the DNAL1 gene are associated with primary ciliary dyskinesia.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119661 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042523 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: dynein".
^ ^a ^b Horváth J, Fliegauf M, Olbrich H, Kispert A, King SM, Mitchison H, Zariwala MA, Knowles MR, Sudbrak R, Fekete G, Neesen J, Reinhardt R, Omran H (July 2005). "Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients". Am. J. Respir. Cell Mol. Biol. 33 (1): 41–7. doi:10.1165/rcmb.2004-0335OC. PMID 15845866. S2CID 19776274.
^ Lancaster MA, Gleeson JG (June 2009). "The primary cilium as a cellular signaling center: lessons from disease". Curr. Opin. Genet. Dev. 19 (3): 220–9. doi:10.1016/j.gde.2009.04.008. PMC 2953615. PMID 19477114.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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