E74 like ets transcription factor 3

E74 like ETS transcription factor 3 is a protein that in humans is encoded by the ELF3 gene.

ELF3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E8P
Identifiers
Aliases	ELF3, EPR-1, ERT, ESE-1, ESX, E74 like ETS transcription factor 3
External IDs	OMIM: 602191; MGI: 1101781; HomoloGene: 3265; GeneCards: ELF3; OMA:ELF3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.1 Start 202,007,945 bp End 202,017,183 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E4 Start 135,181,313 bp End 135,186,306 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa mucosa of transverse colon rectum pancreatic ductal cell gallbladder body of pancreas minor salivary glands islet of Langerhans right uterine tube palpebral conjunctiva Top expressed in corneal stroma pyloric antrum epithelium of stomach mucous cell of stomach blastocyst duodenum colon left colon medulla of thymus crypt of lieberkuhn of small intestine More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity transcription coactivator activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Golgi apparatus cytosol nucleoplasm Biological process cell differentiation regulation of transcription, DNA-templated epithelial cell differentiation regulation of transcription by RNA polymerase II anatomical structure morphogenesis extracellular matrix organization transcription by RNA polymerase II transcription, DNA-templated multicellular organism development positive regulation of transcription, DNA-templated epidermis development inflammatory response negative regulation of transcription, DNA-templated blastocyst development positive regulation of transcription by RNA polymerase II mammary gland involution positive regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1999 13710 Ensembl ENSG00000163435 ENSMUSG00000003051 UniProt P78545 Q3UPW2 RefSeq (mRNA) NM_001114309 NM_004433 NM_001163131 NM_007921 RefSeq (protein) NP_001107781 NP_004424 NP_001156603 NP_031947 Location (UCSC) Chr 1: 202.01 – 202.02 Mb Chr 1: 135.18 – 135.19 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Neve RM, Ylstra B, Chang CH, Albertson DG, Benz CC (May 2002). "ErbB2 activation of ESX gene expression". Oncogene. 21 (24): 3934–8. doi:10.1038/sj.onc.1205503. PMID 12032832.
• Asada S, Choi Y, Yamada M, Wang SC, Hung MC, Qin J, Uesugi M (October 2002). "External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 12747–52. Bibcode:2002PNAS...9912747A. doi:10.1073/pnas.202162199. PMC 130531. PMID 12242338.
• Kwon JH, Keates S, Simeonidis S, Grall F, Libermann TA, Keates AC (January 2003). "ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells". J. Biol. Chem. 278 (2): 875–84. doi:10.1074/jbc.M208241200. PMID 12414801.
• Cabral A, Fischer DF, Vermeij WP, Backendorf C (May 2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation". J. Biol. Chem. 278 (20): 17792–9. doi:10.1074/jbc.M300508200. hdl:1887/50054. PMID 12624109.
• Lee HJ, Chang JH, Kim YS, Kim SJ, Yang HK (September 2003). "Effect of ets-related transcription factor (ERT) on transforming growth factor (TGF)-beta type II receptor gene expression in human cancer cell lines". J. Exp. Clin. Cancer Res. 22 (3): 477–80. PMID 14582709.
• Brown C, Gaspar J, Pettit A, Lee R, Gu X, Wang H, Manning C, Voland C, Goldring SR, Goldring MB, Libermann TA, Gravallese EM, Oettgen P (March 2004). "ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation". J. Biol. Chem. 279 (13): 12794–803. doi:10.1074/jbc.M308593200. PMID 14715662.
• Schedin PJ, Eckel-Mahan KL, McDaniel SM, Prescott JD, Brodsky KS, Tentler JJ, Gutierrez-Hartmann A (March 2004). "ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells". Oncogene. 23 (9): 1766–79. doi:10.1038/sj.onc.1207391. PMID 14767472.
• Wang H, Fang R, Cho JY, Libermann TA, Oettgen P (June 2004). "Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86". J. Biol. Chem. 279 (24): 25241–50. doi:10.1074/jbc.M401356200. PMID 15075319.
• Prescott JD, Koto KS, Singh M, Gutierrez-Hartmann A (June 2004). "The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism". Mol. Cell. Biol. 24 (12): 5548–64. doi:10.1128/MCB.24.12.5548-5564.2004. PMC 419891. PMID 15169914.