EBAG9

Receptor-binding cancer antigen expressed on SiSo cells is a protein that in humans is encoded by the EBAG9 gene.

EBAG9
Identifiers
Aliases	EBAG9, EB9, PDAF, estrogen receptor binding site associated, antigen, 9, estrogen receptor binding site associated antigen 9
External IDs	OMIM: 605772; MGI: 1859920; HomoloGene: 3107; GeneCards: EBAG9; OMA:EBAG9 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q23.2 Start 109,539,711 bp End 109,565,996 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 B3.2 Start 44,482,571 bp End 44,504,911 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland corpus epididymis caput epididymis endothelial cell Achilles tendon kidney tubule tail of epididymis Brodmann area 23 Epithelium of choroid plexus glomerulus Top expressed in seminal vesicula parotid gland submandibular gland atrioventricular valve tail of embryo triceps brachii muscle endocardial cushion genital tubercle migratory enteric neural crest cell ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activator activity involved in apoptotic process Cellular component integral component of membrane Golgi apparatus secretory granule membrane Golgi membrane Biological process regulation of cell growth apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9166 55960 Ensembl ENSG00000147654 ENSMUSG00000022339 UniProt O00559 Q9D0V7 RefSeq (mRNA) NM_198120 NM_001278938 NM_004215 NM_019480 NM_001357690 NM_001357691 RefSeq (protein) NP_001265867 NP_004206 NP_936056 NP_062353 NP_001344619 NP_001344620 Location (UCSC) Chr 8: 109.54 – 109.57 Mb Chr 15: 44.48 – 44.5 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Watanabe T, Inoue S, Hiroi H, Orimo A, Kawashima H, Muramatsu M (1998). "Isolation of Estrogen-Responsive Genes with a CpG Island Library". Mol. Cell. Biol. 18 (1): 442–9. doi:10.1128/mcb.18.1.442. PMC 121513. PMID 9418891.
• Nakashima M, Sonoda K, Watanabe T (1999). "Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1". Nat. Med. 5 (8): 938–42. doi:10.1038/11383. PMID 10426319. S2CID 7513858.
• Ikeda K, Sato M, Tsutsumi O, Tsuchiya F, Tsuneizumi M, Emi M, et al. (2000). "Promoter analysis and chromosomal mapping of human EBAG9 gene". Biochem. Biophys. Res. Commun. 273 (2): 654–60. doi:10.1006/bbrc.2000.2920. PMID 10873660.
• Ohshima K, Nakashima M, Sonoda K, Kikuchi M, Watanabe T (2001). "Expression of RCAS1 and FasL in human trophoblasts and uterine glands during pregnancy: the possible role in immune privilege". Clin. Exp. Immunol. 123 (3): 481–6. doi:10.1046/j.1365-2249.2001.01461.x. PMC 1906005. PMID 11298137.
• Matsushima T, Nakashima M, Oshima K, Abe Y, Nishimura J, Nawata H, et al. (2001). "Receptor binding cancer antigen expressed on SiSo cells, a novel regulator of apoptosis of erythroid progenitor cells". Blood. 98 (2): 313–21. doi:10.1182/blood.V98.2.313.h8000313_313_321. PMID 11435298.
• Tsuneizumi M, Emi M, Nagai H, Harada H, Sakamoto G, Kasumi F, et al. (2002). "Overrepresentation of the EBAG9 gene at 8q23 associated with early-stage breast cancers". Clin. Cancer Res. 7 (11): 3526–32. PMID 11705872.
• Umeoka K, Sanno N, Oyama K, Tahara S, Kurotani R, Ikuyama S, et al. (2002). "Immunohistochemical analysis of RCAS1 in human pituitary adenomas". Mod. Pathol. 14 (12): 1232–6. doi:10.1038/modpathol.3880467. PMID 11743045.
• Hiraoka K, Hida Y, Miyamoto M, Oshikiri T, Suzuoki M, Nakakubo Y, et al. (2002). "High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker". Int. J. Cancer. 99 (3): 418–23. doi:10.1002/ijc.10381. PMID 11992411. S2CID 38086160.
• Rousseau J, Têtu B, Caron D, Malenfant P, Cattaruzzi P, Audette M, et al. (2002). "RCAS1 is associated with ductal breast cancer progression". Biochem. Biophys. Res. Commun. 293 (5): 1544–9. doi:10.1016/S0006-291X(02)00401-1. PMID 12054692.
• Oizumi S, Yamazaki K, Nakashima M, Watanabe T, Hommura F, Ogura S, et al. (2002). "RCAS1 expression: a potential prognostic marker for adenocarcinomas of the lung". Oncology. 62 (4): 333–9. doi:10.1159/000065065. PMID 12138241. S2CID 21506683.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Engelsberg A, Hermosilla R, Karsten U, Schülein R, Dörken B, Rehm A (2003). "The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens". J. Biol. Chem. 278 (25): 22998–3007. doi:10.1074/jbc.M301361200. PMID 12672804.
• Abe Y, Ohshima K, Nakashima M, Hara K, Matsushima T, Choi I, et al. (2003). "Expression of apoptosis-associated protein RCAS1 in macrophages of histiocytic necrotizing lymphadenitis". Int. J. Hematol. 77 (4): 359–63. doi:10.1007/BF02982644. PMID 12774924. S2CID 20918500.
• Takahashi S, Urano T, Tsuchiya F, Fujimura T, Kitamura T, Ouchi Y, et al. (2003). "EBAG9/RCAS1 expression and its prognostic significance in prostatic cancer". Int. J. Cancer. 106 (3): 310–5. doi:10.1002/ijc.11205. PMID 12845666. S2CID 23545565.
• Sonoda K, Miyamoto S, Hirakawa T, Kaku T, Nakashima M, Watanabe T, et al. (2003). "Association between RCAS1 expression and clinical outcome in uterine endometrial cancer". Br. J. Cancer. 89 (3): 546–51. doi:10.1038/sj.bjc.6601126. PMC 2394364. PMID 12888828.
• Leelawat K, Watanabe T, Nakajima M, Tujinda S, Suthipintawong C, Leardkamolkarn V (2003). "Upregulation of tumour associated antigen RCAS1 is implicated in high stages of colorectal cancer". J. Clin. Pathol. 56 (10): 764–8. doi:10.1136/jcp.56.10.764. PMC 1770069. PMID 14514780.
• Ikeguchi M, Ohoro S, Maeda Y, Yamaguchi K, Fukuda K, Shirai H, et al. (2004). "Protein and gene expression of tumor-associated antigen RCAS1 in esophageal squamous cell carcinoma". Oncol. Rep. 10 (6): 1891–4. doi:10.3892/or.10.6.1891. PMID 14534714.
• Ikeguchi M, Hirooka Y, Kaibara N (2004). "Gene and protein expression of RCAS1 in hepatocellular carcinoma". Anticancer Res. 23 (6D): 4967–71. PMID 14981953.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.