Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.[5][6][7]

EGR3
Identifiers
AliasesEGR3, EGR-3, PILOT, early growth response 3
External IDsOMIM: 602419; MGI: 1306780; HomoloGene: 37923; GeneCards: EGR3; OMA:EGR3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199880
NM_001199881
NM_004430

NM_001289925
NM_001289927
NM_018781

RefSeq (protein)

NP_001186809
NP_001186810
NP_004421

NP_001276854
NP_001276856
NP_061251

Location (UCSC)Chr 8: 22.69 – 22.69 MbChr 14: 70.31 – 70.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controlling biological rhythm. It may also play a role in muscle development.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179388Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033730Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP (Aug 1991). "EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors". Oncogene. 6 (6): 917–28. PMID 1906159.
  6. ^ Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD (May 2002). "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". J Biol Chem. 277 (22): 19482–19487. doi:10.1074/jbc.M201687200. PMID 11909874.
  7. ^ a b "Entrez Gene: EGR3 early growth response 3".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.