EIF2C1

Protein argonaute-1 is a protein that in humans is encoded by the EIF2C1 gene.

AGO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SI2, 1SI3, 4KRE, 4KRF, 4KXT
Identifiers
Aliases	AGO1, EIF2C, EIF2C1, GERP95, Q99, hAgo1, argonaute 1, RISC catalytic component, argonaute RISC catalytic component 1, argonaute RISC component 1
External IDs	OMIM: 606228; MGI: 2446630; HomoloGene: 81826; GeneCards: AGO1; OMA:AGO1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.3 Start 35,869,808 bp End 35,930,532 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.2 Start 126,328,805 bp End 126,362,376 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence visceral pleura tendon of biceps brachii parietal pleura ventricular zone hair follicle monocyte internal globus pallidus tibia stromal cell of endometrium Top expressed in Rostral migratory stream superior cervical ganglion ventricular zone ganglionic eminence vestibular labyrinth ciliary body vestibular sensory epithelium otolith organ iris trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II complex binding miRNA binding endoribonuclease activity RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding single-stranded RNA binding RNA binding nucleic acid binding double-stranded RNA binding Cellular component cytoplasm polysome cytosol RISC complex P-body nucleoplasm RISC-loading complex nucleus ribonucleoprotein complex Biological process mRNA destabilization-mediated gene silencing by siRNA regulation of transcription, DNA-templated transcription, DNA-templated pre-miRNA processing nuclear-transcribed mRNA catabolic process positive regulation of gene expression RNA interference miRNA-mediated gene silencing by inhibition of translation RNA secondary structure unwinding mRNA destabilization-mediated gene silencing by miRNA miRNA metabolic process regulation of translation positive regulation of transcription by RNA polymerase II production of miRNAs involved in gene silencing by miRNA positive regulation of NIK/NF-kappaB signaling Wnt signaling pathway, calcium modulating pathway gene silencing regulation of gene silencing by miRNA regulation of megakaryocyte differentiation negative regulation of gene expression negative regulation of angiogenesis RNA phosphodiester bond hydrolysis, endonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26523 236511 Ensembl ENSG00000092847 ENSMUSG00000041530 UniProt Q9UL18 Q8CJG1 RefSeq (mRNA) NM_012199 NM_001317122 NM_001317123 NM_153403 NM_001317173 NM_001317174 NM_001378879 RefSeq (protein) NP_001304051 NP_001304052 NP_036331 NP_001304102 NP_001304103 NP_700452 NP_001365808 Location (UCSC) Chr 1: 35.87 – 35.93 Mb Chr 4: 126.33 – 126.36 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4.

Further reading

• Carmell MA, Xuan Z, Zhang MQ, Hannon GJ (Nov 2002). "The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis". Genes & Development. 16 (21): 2733–42. doi:10.1101/gad.1026102. PMID 12414724.
• Reddy PH, Stockburger E, Gillevet P, Tagle DA (Dec 1997). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics. 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
• Cikaluk DE, Tahbaz N, Hendricks LC, DiMattia GE, Hansen D, Pilgrim D, Hobman TC (Oct 1999). "GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation". Molecular Biology of the Cell. 10 (10): 3357–72. doi:10.1091/mbc.10.10.3357. PMC 25603. PMID 10512872.
• Martinez J, Patkaniowska A, Urlaub H, Lührmann R, Tuschl T (Sep 2002). "Single-stranded antisense siRNAs guide target RNA cleavage in RNAi". Cell. 110 (5): 563–74. doi:10.1016/S0092-8674(02)00908-X. hdl:11858/00-001M-0000-0012-F2FD-2. PMID 12230974. S2CID 10616773.
• Doi N, Zenno S, Ueda R, Ohki-Hamazaki H, Ui-Tei K, Saigo K (Jan 2003). "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors". Current Biology. 13 (1): 41–6. Bibcode:2003CBio...13...41D. doi:10.1016/S0960-9822(02)01394-5. PMID 12526743. S2CID 14650075.
• Ma JB, Ye K, Patel DJ (May 2004). "Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain". Nature. 429 (6989): 318–22. Bibcode:2004Natur.429..318M. doi:10.1038/nature02519. PMC 4700412. PMID 15152257.
• Sen GL, Blau HM (Jun 2005). "Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies". Nature Cell Biology. 7 (6): 633–6. doi:10.1038/ncb1265. PMID 15908945. S2CID 6085169.
• Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (Jul 2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies". Nature Cell Biology. 7 (7): 719–23. doi:10.1038/ncb1274. PMC 1855297. PMID 15937477.
• Chu CY, Rana TM (Jul 2006). "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54". PLOS Biology. 4 (7): e210. doi:10.1371/journal.pbio.0040210. PMC 1475773. PMID 16756390.
• Kim DH, Villeneuve LM, Morris KV, Rossi JJ (Sep 2006). "Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells". Nature Structural & Molecular Biology. 13 (9): 793–7. doi:10.1038/nsmb1142. PMID 16936726. S2CID 26923711.
• Janowski BA, Huffman KE, Schwartz JC, Ram R, Nordsell R, Shames DS, Minna JD, Corey DR (Sep 2006). "Involvement of AGO1 and AGO2 in mammalian transcriptional silencing". Nature Structural & Molecular Biology. 13 (9): 787–92. doi:10.1038/nsmb1140. PMID 16936728. S2CID 2230812.
• Sasaki T, Shimizu N (Jul 2007). "Evolutionary conservation of a unique amino acid sequence in human DICER protein essential for binding to Argonaute family proteins". Gene. 396 (2): 312–20. doi:10.1016/j.gene.2007.04.001. PMID 17482383.