Protein argonaute-1 is a protein that in humans is encoded by the EIF2C1 gene.[5][6][7]

AGO1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAGO1, EIF2C, EIF2C1, GERP95, Q99, hAgo1, argonaute 1, RISC catalytic component, argonaute RISC catalytic component 1, argonaute RISC component 1
External IDsOMIM: 606228; MGI: 2446630; HomoloGene: 81826; GeneCards: AGO1; OMA:AGO1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012199
NM_001317122
NM_001317123

NM_153403
NM_001317173
NM_001317174
NM_001378879

RefSeq (protein)

NP_001304051
NP_001304052
NP_036331

NP_001304102
NP_001304103
NP_700452
NP_001365808

Location (UCSC)Chr 1: 35.87 – 35.93 MbChr 4: 126.33 – 126.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and argonaute 4.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000092847Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041530Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koesters R, Adams V, Betts D, Moos R, Schmid M, Siermann A, Hassam S, Weitz S, Lichter P, Heitz PU, von Knebel Doeberitz M, Briner J (Oct 1999). "Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression". Genomics. 61 (2): 210–8. doi:10.1006/geno.1999.5951. PMID 10534406. S2CID 24461432.
  6. ^ Sasaki T, Shiohama A, Minoshima S, Shimizu N (Sep 2003). "Identification of eight members of the Argonaute family in the human genome". Genomics. 82 (3): 323–30. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857.
  7. ^ a b "Entrez Gene: EIF2C1 eukaryotic translation initiation factor 2C, 1".

Further reading

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