EIF3CL

Eukaryotic translation initiation factor 3 subunit C like is a protein that in humans is encoded by the EIF3CL gene.

EIF3CL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J8B, 3J8C
Identifiers
Aliases	EIF3CL, eukaryotic translation initiation factor 3 subunit C like
External IDs	MGI: 1926966; GeneCards: EIF3CL; OMA:EIF3CL - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p12.1 Start 28,379,579 bp End 28,403,841 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 69.14 cM|7 F3 Start 126,145,627 bp End 126,165,583 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart left ventricle mucosa of transverse colon epithelium of colon right auricle skeletal muscle tissue gastrocnemius muscle anterior cingulate cortex hippocampus proper gonad Top expressed in tail of embryo genital tubercle mandibular prominence maxillary prominence somite endothelial cell of lymphatic vessel Gonadal ridge hair follicle primitive streak dermis More reference expression data BioGPS n/a
Gene ontology Molecular function translation initiation factor binding translation initiation factor activity RNA binding Cellular component cytoplasm eukaryotic translation initiation factor 3 complex eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex Biological process translational initiation protein biosynthesis formation of cytoplasmic translation initiation complex cytoplasmic translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 728689 56347 Ensembl ENSG00000205609 ENSMUSG00000030738 UniProt B5ME19 Q8R1B4 RefSeq (mRNA) NM_001099661 NM_001317856 NM_001317857 NM_146200 RefSeq (protein) NP_001093131 NP_001304785 NP_001304786 NP_666312 Location (UCSC) Chr 16: 28.38 – 28.4 Mb Chr 7: 126.15 – 126.17 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015].

See also

• Eukaryotic initiation factor 3 (eIF3)

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.