ELL3

Elongation factor RNA polymerase II-like 3 is a protein that in humans is encoded by the ELL3 gene.

ELL3
Identifiers
Aliases	ELL3, ELL3 (gene), elongation factor for RNA polymerase II 3
External IDs	OMIM: 609885; MGI: 2673679; HomoloGene: 11859; GeneCards: ELL3; OMA:ELL3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q15.3 Start 43,772,605 bp End 43,777,315 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E5 Start 121,269,491 bp End 121,274,759 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum lymph node zone of skin skin of abdomen skin of leg mucosa of transverse colon left testis right testis rectum testicle Top expressed in spleen morula proximal tubule epiblast primary oocyte embryo right kidney human kidney blastocyst zone of skin More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component nucleolus transcription elongation factor complex nucleus nucleoplasm Biological process positive regulation of DNA-templated transcription, elongation positive regulation of neurogenesis positive regulation of neural precursor cell proliferation transcription elongation from RNA polymerase II promoter regulation of epithelial to mesenchymal transition DNA-templated transcription, elongation regulation of transcription, DNA-templated negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator transcription by RNA polymerase II spermatogenesis positive regulation of transcription by RNA polymerase II stem cell differentiation transcription, DNA-templated negative regulation of signal transduction by p53 class mediator snRNA transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80237 269344 Ensembl ENSG00000128886 ENSMUSG00000027246 UniProt Q9HB65 Q80VR2 RefSeq (mRNA) NM_025165 NM_145973 RefSeq (protein) NP_079441 NP_666085 Location (UCSC) Chr 15: 43.77 – 43.78 Mb Chr 2: 121.27 – 121.27 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Takahashi H, Parmely TJ, Sato S, Tomomori-Sato C, Banks CA, Kong SE, Szutorisz H, Swanson SK, Martin-Brown S, Washburn MP, Florens L, Seidel CW, Lin C, Smith ER, Shilatifard A, Conaway RC, Conaway JW (July 2011). "Human mediator subunit MED26 functions as a docking site for transcription elongation factors". Cell. 146 (1): 92–104. doi:10.1016/j.cell.2011.06.005. PMC 3145325. PMID 21729782.
• Park G, Gong Z, Chen J, Kim JE (April 2010). "Characterization of the DOT1L network: implications of diverse roles for DOT1L". The Protein Journal. 29 (3): 213–23. doi:10.1007/s10930-010-9242-8. PMID 20431927. S2CID 38143958.
• Miller T, Williams K, Johnstone RW, Shilatifard A (October 2000). "Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3". The Journal of Biological Chemistry. 275 (41): 32052–6. doi:10.1074/jbc.M005175200. PMID 10882741.
• Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM, Leung PT, Wang Y (May 2009). "Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins". Proteomics. 9 (9): 2444–56. doi:10.1002/pmic.200800738. PMID 19343720. S2CID 22613066.