ENTPD6

Ectonucleoside triphosphate diphosphohydrolase 6 is an enzyme that in humans is encoded by the ENTPD6 gene.

ENTPD6
Identifiers
Aliases	ENTPD6, CD39L2, IL-6SAG, IL6ST2, NTPDase-6, dJ738P15.3, ectonucleoside triphosphate diphosphohydrolase 6 (putative), ectonucleoside triphosphate diphosphohydrolase 6
External IDs	OMIM: 603160; MGI: 1202295; HomoloGene: 68170; GeneCards: ENTPD6; OMA:ENTPD6 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20p11.21 Start 25,195,693 bp End 25,228,075 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 G3 Start 150,749,042 bp End 150,771,675 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right hemisphere of cerebellum right frontal lobe right auricle nucleus accumbens mucosa of transverse colon middle frontal gyrus anterior pituitary caudate nucleus prefrontal cortex Top expressed in spermatocyte spermatid seminiferous tubule dorsomedial hypothalamic nucleus subiculum paraventricular nucleus of hypothalamus ventromedial nucleus anterior amygdaloid area dentate gyrus of hippocampal formation granule cell lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleoside-triphosphatase activity guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity uridine-diphosphatase activity hydrolase activity nucleoside-diphosphatase activity Cellular component integral component of membrane cell surface Golgi membrane plasma membrane membrane extracellular region extracellular space Golgi apparatus Biological process response to calcium ion response to magnesium ion nucleobase-containing small molecule catabolic process metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 955 12497 Ensembl ENSG00000197586 ENSMUSG00000033068 UniProt O75354 Q5QPI7 Q3U0P5 RefSeq (mRNA) NM_001114089 NM_001247 NM_001317941 NM_001322378 NM_001322379 NM_001322380 NM_001322381 NM_001322382 NM_001322383 NM_001322384 NM_001322385 NM_001322386 NM_001322387 NM_001322388 NM_001322389 NM_001322390 NM_001322391 NM_001322392 NM_001322393 NM_001322394 NM_001322395 NM_001322396 NM_001322397 NM_001322398 NM_172117 NM_001355068 RefSeq (protein) NP_001107561 NP_001238 NP_001304870 NP_001309307 NP_001309308 NP_001309309 NP_001309310 NP_001309311 NP_001309312 NP_001309313 NP_001309314 NP_001309315 NP_001309316 NP_001309317 NP_001309318 NP_001309319 NP_001309320 NP_001309321 NP_001309322 NP_001309323 NP_001309324 NP_001309325 NP_001309326 NP_001309327 NP_742115 NP_001341997 NP_001357558 NP_001357559 NP_001357560 Location (UCSC) Chr 20: 25.2 – 25.23 Mb Chr 2: 150.75 – 150.77 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions, which is characteristic of NTPases.

Further reading

• Chadwick BP, Frischauf AM (Sep 1997). "Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes". Mammalian Genome. 8 (9): 668–72. doi:10.1007/s003359900534. PMID 9271669. S2CID 42644202.
• Hicks-Berger CA, Chadwick BP, Frischauf AM, Kirley TL (Nov 2000). "Expression and characterization of soluble and membrane-bound human nucleoside triphosphate diphosphohydrolase 6 (CD39L2)". The Journal of Biological Chemistry. 275 (44): 34041–5. doi:10.1074/jbc.M004723200. PMID 10948193.
• Yeung G, Mulero JJ, McGowan DW, Bajwa SS, Ford JE (Oct 2000). "CD39L2, a gene encoding a human nucleoside diphosphatase, predominantly expressed in the heart". Biochemistry. 39 (42): 12916–23. doi:10.1021/bi000959z. PMID 11041856.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Ivanenkov VV, Murphy-Piedmonte DM, Kirley TL (Oct 2003). "Bacterial expression, characterization, and disulfide bond determination of soluble human NTPDase6 (CD39L2) nucleotidase: implications for structure and function". Biochemistry. 42 (40): 11726–35. doi:10.1021/bi035137r. PMID 14529283.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.