EPAC may refer to:
- rap guanine nucleotide exchange factor 3 (RAPGEF3), also known as exchange factor directly activated by cAMP 1 (EPAC1) or cAMP-regulated guanine nucleotide exchange factor
- Electrically Power Assisted Cycle, a term used in EU regulations for Electric bicycles
- Eastern Pacific Ocean Hurricane basin
- École Pointe-au-Chien