Ets variant 5

Ets variant 5 (ETV5) (also named ERM transcription factor) is a transcription factor that in humans is encoded by the ETV5 gene. It is generated in Sertoli cells, which are found in the testes and play a crucial role in spermatogenesis. Its ortholog has been linked to both obesity and bipolar disorder.

ETV5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UNO
Identifiers
Aliases	ETV5, ERM, ETS variant 5, ETS variant transcription factor 5
External IDs	OMIM: 601600; MGI: 1096867; HomoloGene: 3276; GeneCards: ETV5; OMA:ETV5 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q27.2 Start 186,046,314 bp End 186,110,318 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B1 Start 22,200,059 bp End 22,258,469 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell ventricular zone secondary oocyte ganglionic eminence caput epididymis Brodmann area 46 prefrontal cortex placenta pituitary gland gonad Top expressed in tail of embryo epiblast lung palate soft palate yolk sac Cortex of frontal lobe embryo primary visual cortex superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus plasma membrane Biological process cell differentiation regulation of transcription, DNA-templated locomotory behavior regulation of branching involved in mammary gland duct morphogenesis positive regulation of transcription, DNA-templated neuromuscular synaptic transmission male germ-line stem cell asymmetric division positive regulation of neuron differentiation skeletal muscle acetylcholine-gated channel clustering cellular response to oxidative stress positive regulation of glial cell proliferation regulation of synapse organization positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2119 104156 Ensembl ENSG00000244405 ENSMUSG00000013089 UniProt P41161 Q9CXC9 RefSeq (mRNA) NM_004454 NM_023794 NM_001358428 RefSeq (protein) NP_004445 NP_076283 NP_001345357 Location (UCSC) Chr 3: 186.05 – 186.11 Mb Chr 16: 22.2 – 22.26 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

ets variant gene 5 (ets-related molecule)
Identifiers
Symbol	ETV5
Alt. symbols	ERM
NCBI gene	2119
HGNC	3494
OMIM	601600
RefSeq	NM_004454
UniProt	P41161
Other data
Locus	Chr. 3 q28
Search for Structures Swiss-model Domains InterPro

Further reading

• T'sas F, Brenner C, Mauen S, Putmans P, Monté D, Van Lint C, Moser M, Baert JL, de Launoit Y (January 2005). "Expression of the Ets transcription factor Erm is regulated through a conventional PKC signaling pathway in the Molt4 lymphoblastic cell line". FEBS Letters. 579 (1): 66–70. Bibcode:2005FEBSL.579...66T. doi:10.1016/j.febslet.2004.11.052. PMID 15620692. S2CID 25112599.
• Brandys MK, van Elburg AA, Loos RJ, Bauer F, Hendriks J, van der Schouw YT, Adan RA (March 2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 153B (2): 695–9. doi:10.1002/ajmg.b.31026. PMID 19746409. S2CID 45793585.
• Colas E, Muinelo-Romay L, Alonso-Alconada L, Llaurado M, Monge M, Barbazan J, Gonzalez M, Schoumacher M, Pedrola N, Ertekin T, Devis L, Ruiz A, Castellvi J, Doll A, Gil-Moreno A, Vazquez-Levin M, Lapyckyj L, Lopez-Lopez R, Robine S, Friederich E, Castro M, Reventos J, Vignjevic D, Abal M (November 2012). "ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas". Oncogene. 31 (45): 4778–88. doi:10.1038/onc.2011.632. hdl:11336/22664. PMID 22266854.
• Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T, Yang Y, Guo Y, Chang C (November 2001). "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells". The Journal of Biological Chemistry. 276 (44): 40417–23. doi:10.1074/jbc.M104765200. PMID 11509567.
• Korz C, Pscherer A, Benner A, Mertens D, Schaffner C, Leupolt E, Döhner H, Stilgenbauer S, Lichter P (June 2002). "Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes". Blood. 99 (12): 4554–61. doi:10.1182/blood.V99.12.4554. PMID 12036888.
• Chotteau-Lelièvre A, Révillion F, Lhotellier V, Hornez L, Desbiens X, Cabaret V, de Launoit Y, Peyrat JP (November 2004). "Prognostic value of ERM gene expression in human primary breast cancers". Clinical Cancer Research. 10 (21): 7297–303. doi:10.1158/1078-0432.CCR-04-0593. PMID 15534105. S2CID 14271353.
• Planagumà J, Liljeström M, Alameda F, Bützow R, Virtanen I, Reventós J, Hukkanen M (January 2011). "Matrix metalloproteinase-2 and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma". Human Pathology. 42 (1): 57–67. doi:10.1016/j.humpath.2010.01.025. PMID 20970160.
• Monge M, Colas E, Doll A, Gil-Moreno A, Castellvi J, Diaz B, Gonzalez M, Lopez-Lopez R, Xercavins J, Carreras R, Alameda F, Canals F, Gabrielli F, Reventos J, Abal M (August 2009). "Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress". Carcinogenesis. 30 (8): 1288–97. doi:10.1093/carcin/bgp119. PMID 19443906.
• Ng MC, Tam CH, So WY, Ho JS, Chan AW, Lee HM, Wang Y, Lam VK, Chan JC, Ma RC (May 2010). "Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese". The Journal of Clinical Endocrinology and Metabolism. 95 (5): 2418–25. doi:10.1210/jc.2009-2077. PMID 20215397.

External links

• ERM+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• ETV5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)