Eakin is an English surname. Notable people with the surname include:
- Bruce Eakin, Canadian ice-hockey player
- Chris Eakin, British newsreader
- Cody Eakin, Canadian ice-hockey player
- Douglas Holtz-Eakin, American economist
- Harvey Eakin, former NASCAR Cup Series driver
- Jake Lee Eakin, American murderer
- John R. Eakin (1822–1885), Justice of the Arkansas Supreme Court
- Kay Eakin (1917–1993), American football player
- Kevin Eakin, American football quarterback
- Michael Eakin, American judge
- Richard M. Eakin (1910–1999), American zoologist
- Richard R. Eakin (born 1938), chancellor of East Carolina University
- Robert Eakin (1848–1917), American judge
- Sue Eakin (1918–2009), American professor
- William Eakin (1828–1918), Canadian politician