Eastlake is a surname. Notable people with the surname include:
- Charles Eastlake (1836–1906), architect and furniture designer
- Sir Charles Lock Eastlake (1793–1865), 19th-century English painter
- Cyril Eastlake (1930–2007), New Zealand rugby league footballer
- Darrell Eastlake (1942–2018), Australian sports commentator
- Elizabeth Eastlake (1809–1893), British art critic and art historian
- William Eastlake (1917–1997), American writer