Ecto-nox disulfide-thiol exchanger 1

Ecto-NOX disulfide-thiol exchanger 1 is a protein that in humans is encoded by the ENOX1 gene. [5]

ENOX1
Identifiers
AliasesENOX1, CNOX, PIG38, bA64J21.1, cCNOX, ecto-NOX disulfide-thiol exchanger 1
External IDsOMIM: 610914; MGI: 2444896; HomoloGene: 56793; GeneCards: ENOX1; OMA:ENOX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253759
NM_172813

RefSeq (protein)

NP_001240688
NP_766401

Location (UCSC)Chr 13: 43.21 – 43.79 MbChr 14: 77.16 – 77.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Electron transport pathways are generally associated with mitochondrial membranes, but non-mitochondrial pathways are also biologically significant. Plasma membrane electron transport pathways are involved in functions as diverse as cellular defense, intracellular redox homeostasis, and control of cell growth and survival. Members of the ecto-NOX family, such as CNOX, or ENOX1, are involved in plasma membrane transport pathways. These enzymes exhibit both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity in series, with each activity cycling every 22 to 26 minutes (Scarlett et al., 2005 [PubMed 15882838]).

See also

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Ecto-nox disulfide-thiol exchanger 2

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120658Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022012Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ecto-NOX disulfide-thiol exchanger 1". Retrieved 2017-02-17.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.