Edward Cross may refer to:
- Edward Cross (politician) (1798–1887), judge, attorney general, and politician in Arkansas who served as a member of the United States House of Representatives from the state of Arkansas
- Edward E. Cross (1832–1863), newspaperman and Union Army general during the American Civil War
- Edward Cross (zoo proprietor) (1774–1854), English zoo proprietor and dealer in animals
- Edward Cross (footballer), English footballer who played for Sheffield United
- Edward Makin Cross (1880–1965), bishop of Spokane in the Episcopal Church