Eldelumab (alternative identifier BMS-936557[1]) is a fully human monoclonal antibody (type IgG1 kappa)[2] that targets chemokine (C-X-C motif) ligand 10 (CXCL10)/Interferon-γ-inducible protein-10 (IP-10)[2][1] designed for the treatment of Crohn's disease and ulcerative colitis.[3]
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | CXCL10/IP-10 |
| Clinical data | |
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| CAS Number | |
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| Chemical and physical data | |
| Formula | C6502H10024N1736O2026S48 |
| Molar mass | 146468.72 g·mol−1 |
This drug was developed by Bristol-Myers Squibb and Medarex.[4]
References
edit- ^ a b Sandborn WJ, Colombel JF, Ghosh S, Sands BE, Dryden G, Hébuterne X, et al. (April 2016). "Eldelumab [Anti-IP-10] Induction Therapy for Ulcerative Colitis: A Randomised, Placebo-Controlled, Phase 2b Study". Journal of Crohn's & Colitis. 10 (4): 418–28. doi:10.1093/ecco-jcc/jjv224. PMC 4946756. PMID 26721935.
- ^ a b "Anti-CXCL10 Therapeutic Antibody (eldelumab) - Creative Biolabs". www.creativebiolabs.net. Retrieved 2017-03-24.
- ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Eldelumab, American Medical Association.
- ^ "Eldelumab". AdisInsight. Springer Nature Switzerland AG.
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