Elizabeth Murphy Topp is an American pharmaceutical scientist and educator known for her work in solid‐state chemical stability of proteins and peptides. In 2000s Topp introduced solid-state hydrogen-deuterium exchange as the method for stability characterization of lyophilized biopharmaceutical formulations.[2][3] She is the Chief Scientific Officer at National Institute of Bioprocessing Research and Training (NIBRT) in Dublin, Ireland since September 2019.[4] Topp was on the faculty at the University of Kansas Department of Pharmaceutical Chemistry from 1986 to 2009.[5] She has been the Head and Dane O. Kildsig Chair at the Department of Industrial and Physical Chemistry at Purdue University College of Pharmacy from 2009 to 2017.[6] Topp has been elected a fellow of American Association of Pharmaceutical Scientists in 2010 for "making sustained remarkable scholarly and research contributions to the pharmaceutical sciences".[7] In 2015 Topp co-founded, with Alina Alexeenko, an industry-university consortium LyoHUB for advancing pharmaceutical lyophilization technology.[8]
Elizabeth Topp | |
|---|---|
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| Alma mater | University of Delaware, University of Michigan |
| Scientific career | |
| Fields | |
| Institutions | Purdue University |
| Thesis | A Physiological Flow Model for the Gastrointestinal Absorption and Plasma Kinetics of Aspirin[1] (1986) |
| Doctoral advisor | Gordon Amidon |
Topp earned her B.S. in Chemical Engineering form the University of Delaware, M.E. in Chemical and Biochemical Engineering from the University of Pennsylvania and a Ph.D. in Pharmaceutics from University of Michigan.[9][10]
References
edit- ^ "A PHYSIOLOGICAL FLOW MODEL FOR THE GASTROINTESTINAL ABSORPTION AND PLASMA KINETICS OF ASPIRIN". ProQuest.
- ^ Li, Yunsong; Williams, Todd D.; Topp, Elizabeth M. (2008). "Effects of excipients on protein conformation in lyophilized solids by hydrogen/deuterium exchange mass spectrometry". Pharmaceutical Research. 25 (2): 259–267. doi:10.1007/s11095-007-9365-6. PMID 17597380. S2CID 3185438.
- ^ Li, Yunsong; Williams, Todd D.; Schowen, Richard L.; Topp, Elizabeth M. (2007). "Characterizing protein structure in amorphous solids using hydrogen/deuterium exchange with mass spectrometry". Analytical Biochemistry. 366 (1): 18–28. doi:10.1016/j.ab.2007.03.041. PMID 17490599.
- ^ "NIBRT announces appointment of Purdue's Elizabeth Topp as Chief Scientific Officer". 5 September 2019.
- ^ https://apps.pharmacy.purdue.edu/directory/publications/topp_cv.pdf
- ^ "Elizabeth Topp". National Institute for Bioprocessing Research. Retrieved 2023-08-17.
- ^ "AAPS announces 2010 Fellows: 18 honored for outstanding contributions to the pharmaceutical sciences".
- ^ "Purdue to advance freeze-drying technology through rocket science".
- ^ "Aug. 14: Pharma prof speaks". www.udel.edu. Retrieved 2023-08-17.
- ^ "Elizabeth M. Topp | IPPH". www.ipph.purdue.edu. Retrieved 2023-08-17.
External links
edit- Elizabeth Topp publications indexed by Google Scholar