Empress Dowager Guo may refer to:
- Guo Nüwang (184–235), Cao Pi's wife and empress dowager during the Cao Wei
- Empress Guo (Cao Rui's wife) (died 263), consort and empress dowager during the Cao Wei
- Empress Dowager Guo (Tang dynasty) (died 848), consort and empress dowager during the Tang dynasty