Endo-α-sialidase (EC 3.2.1.129, endo-N-acylneuraminidase, endoneuraminidase, endo-N-acetylneuraminidase, poly(α-2,8-sialosyl) endo-N-acetylneuraminidase, poly(α-2,8-sialoside) α-2,8-sialosylhydrolase, endosialidase, endo-N) is an enzyme with systematic name polysialoside (2→8)-α-sialosylhydrolase.[1][2][3][4][5][6][7] It catalyses the following chemical reaction:
| Endo-α-sialidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.2.1.129 | ||||||||
| CAS no. | 91195-87-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- Endohydrolysis of (2→8)-α-sialosyl linkages in oligo- or poly(sialic) acids
References
edit- ^ Finne J, Mäkelä PH (January 1985). "Cleavage of the polysialosyl units of brain glycoproteins by a bacteriophage endosialidase. Involvement of a long oligosaccharide segment in molecular interactions of polysialic acid". The Journal of Biological Chemistry. 260 (2): 1265–70. doi:10.1016/S0021-9258(20)71238-X. PMID 3968060.
- ^ Hallenbeck PC, Vimr ER, Yu F, Bassler B, Troy FA (March 1987). "Purification and properties of a bacteriophage-induced endo-N-acetylneuraminidase specific for poly-α-2,8-sialosyl carbohydrate units". The Journal of Biological Chemistry. 262 (8): 3553–61. doi:10.1016/S0021-9258(18)61387-0. PMID 3546309.
- ^ Kitajima K, Inoue S, Inoue Y, Troy FA (December 1988). "Use of a bacteriophage-derived endo-N-acetylneuraminidase and an equine antipolysialyl antibody to characterize the polysialyl residues in salmonid fish egg polysialoglycoproteins. Substrate and immunospecificity studies". The Journal of Biological Chemistry. 263 (34): 18269–76. doi:10.1016/S0021-9258(19)81355-8. PMID 3142874.
- ^ Kwiatkowski B, Boschek B, Thiele H, Stirm S (August 1982). "Endo-N-acetylneuraminidase associated with bacteriophage particles". Journal of Virology. 43 (2): 697–704. doi:10.1128/JVI.43.2.697-704.1982. PMC 256172. PMID 7109038.
- ^ Pelkonen S, Pelkonen J, Finne J (October 1989). "Common cleavage pattern of polysialic acid by bacteriophage endosialidases of different properties and origins". Journal of Virology. 63 (10): 4409–16. doi:10.1128/JVI.63.10.4409-4416.1989. PMC 251059. PMID 2778882.
- ^ Tomlinson S, Taylor PW (August 1985). "Neuraminidase associated with coliphage E that specifically depolymerizes the Escherichia coli K1 capsular polysaccharide". Journal of Virology. 55 (2): 374–8. doi:10.1128/JVI.55.2.374-378.1985. PMC 254943. PMID 3894684.
- ^ Cabezas JA (August 1991). "Some questions and suggestions on the type references of the official nomenclature (IUB) for sialidase(s) and endosialidase". The Biochemical Journal. 278 ( Pt 1) (Pt 1): 311–2. doi:10.1042/bj2780311. PMC 1151486. PMID 1883340.
External links
edit- Endo-alpha-sialidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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