Endothelin-converting enzyme 1

Endothelin-converting enzyme 1 (EC 3.4.24.71, endothelin-converting enzyme, ECE-1) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Endothelin-converting enzyme 1
Identifiers
EC no.3.4.24.71
CAS no.138238-81-0
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BRENDABRENDA entry
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MetaCycmetabolic pathway
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Hydrolysis of the -Trp21-Val- bond in big endothelin to form endothelin 1

This metalloendopeptidase belongs to the peptidase family M13.

References

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  1. ^ Takahashi M, Matsushita Y, Iijima Y, Tanzawa K (October 1993). "Purification and characterization of endothelin-converting enzyme from rat lung". The Journal of Biological Chemistry. 268 (28): 21394–8. doi:10.1016/S0021-9258(19)36936-4. PMID 8407980.
  2. ^ Shimada K, Takahashi M, Tanzawa K (July 1994). "Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells". The Journal of Biological Chemistry. 269 (28): 18275–8. doi:10.1016/S0021-9258(17)32298-6. PMID 8034569.
  3. ^ Xu D, Emoto N, Giaid A, Slaughter C, Kaw S, deWit D, Yanagisawa M (August 1994). "ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1". Cell. 78 (3): 473–85. doi:10.1016/0092-8674(94)90425-1. PMID 8062389. S2CID 7872049.
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