Enhancer of polycomb homolog 2 (drosophila)

Enhancer of polycomb homolog 2 (Drosophila) is a protein that in humans is encoded by the EPC2 gene.

EPC2
Identifiers
Aliases	EPC2, EPC-LIKE, enhancer of polycomb homolog 2
External IDs	OMIM: 611000; MGI: 1278321; HomoloGene: 32274; GeneCards: EPC2; OMA:EPC2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q23.1 Start 148,644,440 bp End 148,787,569 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 C1.1|2 28.62 cM Start 49,341,498 bp End 49,441,960 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium Achilles tendon ganglionic eminence ventricular zone endothelial cell sural nerve bone marrow cells corpus callosum amniotic fluid monocyte Top expressed in hand substantia nigra ureter zygote lobe of cerebellum cerebellar vermis medullary collecting duct fossa lateral septal nucleus ventromedial nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function histone acetyltransferase activity Cellular component nucleus NuA4 histone acetyltransferase complex Piccolo NuA4 histone acetyltransferase complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated cellular response to DNA damage stimulus DNA repair regulation of transcription by RNA polymerase II histone acetylation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26122 227867 Ensembl ENSG00000135999 ENSMUSG00000069495 UniProt Q52LR7 Q8C0I4 RefSeq (mRNA) NM_015630 NM_172663 RefSeq (protein) NP_056445 NP_766251 Location (UCSC) Chr 2: 148.64 – 148.79 Mb Chr 2: 49.34 – 49.44 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W, Lane WS, Tan S, Yang XJ, Côté J (January 2006). "ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation". Molecular Cell. 21 (1): 51–64. doi:10.1016/j.molcel.2005.12.007. PMID 16387653.
• Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, Cantor AB, Orkin SH (October 2010). "A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs". Cell. 143 (2): 313–24. doi:10.1016/j.cell.2010.09.010. PMC 3018841. PMID 20946988.
• Kim S, Swaminathan S, Shen L, Risacher SL, Nho K, Foroud T, Shaw LM, Trojanowski JQ, Potkin SG, Huentelman MJ, Craig DW, DeChairo BM, Aisen PS, Petersen RC, Weiner MW, Saykin AJ (January 2011). "Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort". Neurology. 76 (1): 69–79. doi:10.1212/WNL.0b013e318204a397. PMC 3030225. PMID 21123754.
• Doyon Y, Selleck W, Lane WS, Tan S, Côté J (March 2004). "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans". Molecular and Cellular Biology. 24 (5): 1884–96. doi:10.1128/MCB.24.5.1884-1896.2004. PMC 350560. PMID 14966270.
• Hayakawa T, Zhang F, Hayakawa N, Ohtani Y, Shinmyozu K, Nakayama J, Andreassen PR (April 2010). "MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks". Journal of Cell Science. 123 (Pt 7): 1124–30. doi:10.1242/jcs.060178. PMC 2844321. PMID 20332121.
• Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, Rafferty I, et al. (May 2008). "A genome-wide association study identifies protein quantitative trait loci (pQTLs)". PLOS Genetics. 4 (5): e1000072. doi:10.1371/journal.pgen.1000072. PMC 2362067. PMID 18464913.
• Hayakawa T, Ohtani Y, Hayakawa N, Shinmyozu K, Saito M, Ishikawa F, Nakayama J (June 2007). "RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation". Genes to Cells. 12 (6): 811–26. doi:10.1111/j.1365-2443.2007.01089.x. PMID 17573780. S2CID 10003129.
• Guil S, Soler M, Portela A, Carrère J, Fonalleras E, Gómez A, Villanueva A, Esteller M (June 2012). "Intronic RNAs mediate EZH2 regulation of epigenetic targets". Nature Structural & Molecular Biology. 19 (7): 664–70. doi:10.1038/nsmb.2315. PMID 22659877. S2CID 14906359.
• Huang X, Spencer GJ, Lynch JT, Ciceri F, Somerville TD, Somervaille TC (May 2014). "Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells". Leukemia. 28 (5): 1081–91. doi:10.1038/leu.2013.316. PMC 3998875. PMID 24166297.