Enola Holmes may refer to:
- Enola Holmes (character), a non-canonical younger sister of Sherlock Holmes created by author Nancy Springer
- The Enola Holmes Mysteries, the book series featuring the character
- Enola Holmes (film), a 2020 film based on the first book
- Enola Holmes (soundtrack)
- Enola Holmes 2, the 2022 sequel to the 2020 film
- Enola Holmes 2 (soundtrack)