Enrique Rodríguez may refer to:
- Enrique Rodríguez (boxer) (1951–2022), Olympic boxer from Spain
- Enrique Rodríguez (rugby union) (born 1952), Argentine and Australian rugby union international
- Enrique Rodríguez Galindo (1939–2021), brigadier-general in the Spanish Civil Guard
- Enrique Rodríguez Negrón (born 1933), Puerto Rican senator
- Enrique Rodríguez Uresti (born 1962), Mexican politician
- Enrique Ramos Rodríguez (born 1932), Mexican politician