Ent-isokaurene C2-hydroxylase (EC 1.14.13.143, CYP71Z6) is an enzyme with systematic name ent-isokaurene,NADPH:oxygen oxidoreductase (hydroxylating).[1] This enzyme catalyses the following chemical reaction
| Ent-isokaurene C2-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.143 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- ent-isokaurene + O2 + NADPH + H+ ent-2alpha-hydroxyisokaurene + H2O + NADP+
Ent-isokaurene C2-hydroxylase performs the initial step in the conversion of ent-isokaurene to the antibacterial oryzalides in rice, Oryza sativa.
References
edit- ^ Wu Y, Hillwig ML, Wang Q, Peters RJ (November 2011). "Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7". FEBS Letters. 585 (21): 3446–51. doi:10.1016/j.febslet.2011.09.038. PMC 3227696. PMID 21985968.
External links
edit- Ent-isokaurene+C2-hydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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