Enzio (Italian: [ˈɛntsjo]) may refer to
- Enzio or Enzo of Sardinia (1218–1272), illegitimate son of Holy Roman Emperor Frederick II
- Enzio, legitimate son of Manfred of Sicily by his wife Helena; he was confined to prison his entire life
- Enzio Boldewijn (born 1992), Dutch footballer
- Enzio d'Antonio (1925–2019), Italian Roman Catholic bishop and archbishop
- Enzio von Pfeil (born 1953), German economist
- Enzio Reuter (1867–1951), Finnish entomologist