Epithelial stromal interaction 1

Epithelial stromal interaction 1 is a protein that in humans is encoded by the EPSTI1 gene. [5]

EPSTI1
Identifiers
AliasesEPSTI1, BRESI1, epithelial stromal interaction 1 (breast), epithelial stromal interaction 1
External IDsOMIM: 607441; MGI: 1915168; HomoloGene: 12630; GeneCards: EPSTI1; OMA:EPSTI1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002264
NM_033255
NM_001330543
NM_001331228

NM_029495
NM_178825

RefSeq (protein)

NP_001002264
NP_001317472
NP_001318157
NP_150280

NP_083771
NP_849147

Location (UCSC)Chr 13: 42.89 – 42.99 MbChr 14: 78.14 – 78.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene has been shown to promote tumor invasion and metastasis in some invasive cancer cells when overexpressed. Expression of this gene has been shown to be upregulated by direct binding of the Kruppel like factor 8 protein to promoter sequences. The translated protein interacts with the amino terminal region of the valosin containing protein gene product, resulting in the nuclear translocation of the nuclear factor kappa B subunit 1 gene product, and activation of target genes. Overexpression of this gene has been observed in some breast cancers and in some individuals with systemic lupus erythematosus (SLE).

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133106Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022014Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Epithelial stromal interaction 1". Retrieved 2017-09-16.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.