Escamilla is a surname. Notable people with the surname include:
- Cuitlahuac Condado Escamilla (born 1978), Mexican politician
- Dolores Guadalupe García Escamilla (c. 1966–2005), Mexican crime reporter and anchorwoman
- Ignacio Escamilla (born 1967), Mexican swimmer
- Jorge Escamilla (born 1995), Mexican footballer
- Juan Carlos Escamilla (born 1978), American politician
- Kevin Escamilla (born 1994), Mexican footballer
- Raymundo Escamilla (born 1964), Mexican politician