Estradiol benzoate/progesterone/testosterone propionate (EB/P4/TP), sold under the brand names Lukestra, Steratrin, Trihormonal, and Trinestryl, is an injectable combination medication of estradiol benzoate (EB), an estrogen, progesterone (P4), a progestogen, and testosterone propionate (TP), an androgen/anabolic steroid.[1][2][3][4][5] It contained 1 to 3 mg EB, 20 to 25 mg P4, and 25 mg TP, was provided in the form of ampoules, and was administered by intramuscular injection.[1][2][3][4][6] The medication was introduced by 1949 and was marketed in the United States, the United Kingdom, and Germany among other places.[7][8][5] It is no longer available.[9][10]
| Combination of | |
|---|---|
| Estradiol benzoate | Estrogen |
| Progesterone | Progestogen |
| Testosterone propionate | Androgen; Anabolic steroid |
| Clinical data | |
| Trade names | Lukestra, Steratrin, Trihormonal, Trinestryl |
| Other names | EB/P4/TP |
| Routes of administration | Intramuscular injection |
See also
editReferences
edit- ^ a b Silló G (9 March 2013). "Komplexhormon bei Menopause und Hypertonie" [Complex hormone for menopause and hypertension]. In Nowakowski H (ed.). Hormone und Psyche die Endokrinologie des Alternden Menschen: Fünftes Symposion der Deutschen Gesellschaft für Endokrinologie Freiburg (Breisgau), den 7. bis 9. März 1957 [Hormones and Psyche the Endocrinology of Aging People: Fifth Symposium of the German Society for Endocrinology Freiburg (Breisgau), March 7th to 9th, 1957]. Springer-Verlag. pp. 55–. ISBN 978-3-642-87014-9.
- ^ a b Hager HH, Kern W, List PH, Roth HJ (29 July 2013). "Hormone". Hagers Handbuch der Pharmazeutischen Praxis: Für Apotheker, Arzneimittelhersteller, Ärzte und Medizinalbeamte: Wirkstoffgruppen II Chemikalien und Drogen (A-AL). Springer-Verlag. pp. 187–. ISBN 978-3-662-25655-8.
- ^ a b Walther K, Auterhoff H, Neuwald F, Schmid W (9 March 2013). "Hormone". Hagers Handbuch der Pharmazeutischen Praxis: Für Apotheker, Arzneimittelhersteller, Drogisten, Ärzte und Medizinalbeamte. Springer-Verlag. pp. 1163–. ISBN 978-3-642-49759-9.
- ^ a b Ufer J (1960). Hormontherapie in der Frauenheilkunde: Grundlagen und Praxis. de Gruyter. p. 155. ISBN 9783111138770.
- ^ a b Bishop PM (1962). Chemistry of the Sex Hormones. Thomas. p. 85.
Lukestra Injection Steroid Triad (oestradiol benz., test. prop. and progesterone) Merck, Sharp & Dohme
- ^ Greenblatt RB, Barfield WE (January 1952). "Hormonal control of functional uterine bleeding". American Journal of Obstetrics and Gynecology. 63 (1): 153–157. doi:10.1016/s0002-9378(16)38992-x. PMID 14894511. S2CID 6863371.
The estrogen-progesterone-testosterone combinations used in our studies were supplied by the following pharmaceutical companies: Wyeth, Inc.: Tristerone (6 mg. estrone, 50 mg. progesterone, 25 mg. testosterone). Schering Corporation: Steratrin (1 mg. estradiol benzoate, 25 mg. progesterone, 25 mg. testoterone propionate).Sharp and Dohme, Inc.: Lukestra (1.66 mg. estradiol benzoate, 25 mg. progesterone, 25 mg. testosterone propionate).
- ^ United States. Patent Office (1950). Official Gazette of the United States Patent Office. U.S. Patent Office. pp. 31–.
- ^ Unlisted Drugs. Unlisted Drugs Committee of the Pharmaceutical Section, Science-Technology Group, Special Libraries Association. 1952.
Lukestra C. each cc, contains: estradiol benzoate, 1.67 mg.; progesterone, 25 mg.; and testosterone propionate, 25 mg.
- ^ "?". IBM Watson Health.
- ^ "Estradiol". Drugs.com.
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