Etilefrine pivalate INNTooltip International Nonproprietary Name; developmental code name K-30052) is a sympathomimetic agent which was never marketed.[1][2] It is the 3-pivalate ester of etilefrine (ethylnorphenylephrine) and has much greater lipophilicity than etilefrine.[1][3] Some related compounds include pivenfrine (phenylephrine pivalate) and dipivefrine (epinephrine dipivalate), which were developed as mydriatic agents.[1]

Etilefrine pivalate
Clinical data
Other namesEtilephrine pivalate; Ethylnorphenylephrine pivalate; Pivalyletilefrine; 3,β-Dihydroxy-N-ethylphenethylamine 3-pivalate
Identifiers
  • [3-[2-(ethylamino)-1-hydroxyethyl]phenyl] 2,2-dimethylpropanoate
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H23NO3
Molar mass265.353 g·mol−1
3D model (JSmol)
  • CCNCC(C1=CC(=CC=C1)OC(=O)C(C)(C)C)O
  • InChI=1S/C15H23NO3/c1-5-16-10-13(17)11-7-6-8-12(9-11)19-14(18)15(2,3)4/h6-9,13,16-17H,5,10H2,1-4H3
  • Key:DRMHNJGOEAYOIZ-UHFFFAOYSA-N

References

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  1. ^ a b c Elks J (2014). "A-00272: 2-Amino-1-(3-hydroxyphenyl)ethanol: Etilefrine pivalate". The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. pp. 61, 455, 1001. ISBN 978-1-4757-2085-3. Retrieved 1 September 2024.
  2. ^ Morton IK, Hall JM (2012). "Etilefrine". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Netherlands. p. 116. ISBN 978-94-011-4439-1. Retrieved 2024-09-01.
  3. ^ "Etilefrine pivalate". PubChem. U.S. National Library of Medicine. Retrieved 1 September 2024.