Exodeoxyribonuclease I (EC 3.1.11.1, Escherichia coli exonuclease I, E. coli exonuclease I, exonuclease I) is an enzyme[1][2][3] that catalyses the following chemical reaction:
| Exodeoxyribonuclease I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.11.1 | ||||||||
| CAS no. | 9037-46-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- Exonucleolytic cleavage in the 3′- to 5′-direction to yield nucleoside 5′-phosphates
Preference for[clarification needed] single-stranded DNA. The Escherichia coli enzyme hydrolyses glucosylated DNA. Punjabi
References
edit- ^ Blakesley RW, Dodgson JB, Nes IF, Wells RD (October 1977). "Duplex regions in "single-stranded" phiX174 DNA are cleaved by a restriction endonuclease from Haemophilus aegyptius". The Journal of Biological Chemistry. 252 (20): 7300–6. doi:10.1016/S0021-9258(19)66969-3. PMID 71298.
- ^ Kelley RB, Atkinson MR, Huberman JA, Kornberg A (1969). "Excision of thymine dimers and other mismatched sequences by DNA polymerases of Escherichia coli". Nature. 224 (5218): 495–501. Bibcode:1969Natur.224..495K. doi:10.1038/224495a0.
- ^ Lehman IR, Nussbaum AL (August 1964). "The deoxyribonucleases of Escherichia coli. V. On the specificity of exonuclease I (phosphodiesterase)". The Journal of Biological Chemistry. 239 (8): 2628–36. doi:10.1016/S0021-9258(18)93898-6. PMID 14235546.
External links
edit- Exodeoxyribonuclease+I at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
