FAM114A2 (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. The protein function is not well known. FAM114A2 is, however, highly conserved in mammals with homologs both in fungi and plants.

FAM114A2
Identifiers
AliasesFAM114A2, 133K02, C5orf3, family with sequence similarity 114 member A2
External IDsMGI: 1917629; HomoloGene: 10270; GeneCards: FAM114A2; OMA:FAM114A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018691
NM_001317993
NM_001317994
NM_001317995

NM_001168667
NM_001168668
NM_026342

RefSeq (protein)

NP_001304922
NP_001304923
NP_001304924
NP_061161

NP_001162138
NP_001162139
NP_080618

Location (UCSC)Chr 5: 153.99 – 154.04 MbChr 11: 57.37 – 57.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Species Accession # Identity
macaca mulatta XM_001102467 78.1%
Pan troglodytes XM_518045 89.7%
bos taurus NP_001033166 85.6%
Pongo abelii XM_002816109 87.8%
Mus musculus NM_026342.3 79%
Callithrix jacchus XP_002744467 94.7%

Protein

edit

The FAM114A2 protein is 505 amino acids long[5] with a molecular weight of 55.5 kdal and an isoelectric point of 4.66.[6] It is predicted to stay in the nucleus after translation [7] There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 [8] This protein is thought to include a P loop[9] that suggests a role in ATP- and/or GTP-binding [10]

Gene

edit

The FAM114A2 gene is located on chromosome 5 (5q31-33).[11] This gene has 14 exons spanning through its sequence.[5] The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs.[5] It is expressed at high levels in most tissues of the human body.[11] It is also highly expressed in tissues in the human brain [12]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000055147Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020523Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Homo sapiens family with sequence similarity 114, member A2 (FAM114A2) - Nucleotide - NCBI
  6. ^ Biology workbench: http://seqtool.sdsc.edu/CGI/BW.cgi#[permanent dead link]!
  7. ^ PSORT WWW Server
  8. ^ STRING: http://string-db.org/newstring_cgi/show_network_section.pl.
  9. ^ "STRING: Functional protein association networks".
  10. ^ Saraste M, Sibbald PR, Wittinghofer A (November 1990). "The P-loop--a common motif in ATP- and GTP-binding proteins". Trends Biochem. Sci. 15 (11): 430–4. doi:10.1016/0968-0004(90)90281-f. PMID 2126155.
  11. ^ a b FAM114A2 Gene - GeneCards | F1142 Protein | F1142 Antibody
  12. ^ Allen Brain Atlas: http://human.brain-map.org/search?type=mi Archived 2011-08-18 at the Wayback Machine
edit

Further reading

edit