FBP1

Fructose-1,6-bisphosphatase 1 is a protein that in humans is encoded by the FBP1 gene.

FBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FTA, 2FHY, 2FIE, 2FIX, 2JJK, 2VT5, 2WBB, 2WBD, 2Y5K, 2Y5L, 3A29, 3KBZ, 3KC0, 3KC1, 4MJO
Identifiers
Aliases	FBP1, FBP, fructose-bisphosphatase 1
External IDs	OMIM: 611570; MGI: 95492; HomoloGene: 55467; GeneCards: FBP1; OMA:FBP1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.32 Start 94,603,133 bp End 94,640,249 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 B3 Start 63,012,567 bp End 63,036,096 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver jejunal mucosa mucosa of ileum duodenum human kidney right lung upper lobe of left lung kidney tubule monocyte mucosa of transverse colon Top expressed in left lobe of liver right kidney human kidney seminiferous tubule gallbladder spermatocyte spermatid proximal tubule epithelium of small intestine Ileal epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding phosphoric ester hydrolase activity identical protein binding hydrolase activity catalytic activity monosaccharide binding AMP binding phosphatase activity fructose 1,6-bisphosphate 1-phosphatase activity Cellular component cytoplasm extracellular exosome cytosol nucleus Biological process fructose metabolic process fructose 6-phosphate metabolic process cellular response to magnesium ion metabolism dephosphorylation regulation of gluconeogenesis negative regulation of cell growth protein homotetramerization negative regulation of Ras protein signal transduction gluconeogenesis sucrose biosynthetic process fructose 1,6-bisphosphate metabolic process carbohydrate metabolic process negative regulation of transcription by RNA polymerase II negative regulation of glycolytic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2203 14121 Ensembl ENSG00000165140 ENSMUSG00000069805 UniProt P09467 Q9QXD6 RefSeq (mRNA) NM_000507 NM_001127628 NM_019395 RefSeq (protein) NP_000498 NP_001121100 NP_062268 Location (UCSC) Chr 9: 94.6 – 94.64 Mb Chr 13: 63.01 – 63.04 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.

Further reading

• Yáñez AJ, Bertinat R, Spichiger C, Carcamo JG, de Los Angeles García M, Concha II, Nualart F, Slebe JC (Oct 2005). "Novel expression of liver FBPase in Langerhans islets of human and rat pancreas". Journal of Cellular Physiology. 205 (1): 19–24. doi:10.1002/jcp.20407. hdl:10533/176131. PMID 15965961. S2CID 40822845.
• Faiyaz-Ul-Haque M, Al-Owain M, Al-Dayel F, Al-Hassnan Z, Al-Zaidan H, Rahbeeni Z, Al-Sayed M, Balobaid A, Cluntun A, Toulimat M, Abalkhail H, Peltekova I, Zaidi SH (Dec 2009). "Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency". European Journal of Pediatrics. 168 (12): 1467–71. doi:10.1007/s00431-009-0953-9. PMID 19259699. S2CID 23777808.
• Kikawa Y, Inuzuka M, Takano T, Shigematsu Y, Nakai A, Yamamoto Y, Jin BY, Koga J, Taketo A, Sudo M (Mar 1994). "cDNA sequences encoding human fructose 1,6-bisphosphatase from monocytes, liver and kidney: application of monocytes to molecular analysis of human fructose 1,6-bisphosphatase deficiency". Biochemical and Biophysical Research Communications. 199 (2): 687–93. doi:10.1006/bbrc.1994.1283. PMID 8135811.
• Besançon F, Just J, Bourgeade MF, Van Weyenbergh J, Solomon D, Guillozo H, Wietzerbin J, Cayre YE (Aug 1997). "HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase". Journal of Interferon & Cytokine Research. 17 (8): 461–7. doi:10.1089/jir.1997.17.461. PMID 9282826.
• Gizak A, Maciaszczyk-Dziubinska E, Jurowicz M, Rakus D (Nov 2009). "Muscle FBPase is targeted to nucleus by its 203KKKGK207 sequence". Proteins. 77 (2): 262–7. doi:10.1002/prot.22506. PMID 19626708. S2CID 22934928.
• Zhang Y, Liang JY, Huang S, Ke H, Lipscomb WN (Feb 1993). "Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase". Biochemistry. 32 (7): 1844–57. doi:10.1021/bi00058a019. PMID 8382525.
• Visinoni S, Khalid NF, Joannides CN, Shulkes A, Yim M, Whitehead J, Tiganis T, Lamont BJ, Favaloro JM, Proietto J, Andrikopoulos S, Fam BC (May 2012). "The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity". Diabetes. 61 (5): 1122–32. doi:10.2337/db11-1511. PMC 3331739. PMID 22517657.
• Liu X, Wang X, Zhang J, Lam EK, Shin VY, Cheng AS, Yu J, Chan FK, Sung JJ, Jin HC (Jan 2010). "Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis". Oncogene. 29 (3): 442–50. doi:10.1038/onc.2009.332. PMID 19881551.
• Kikawa Y, Inuzuka M, Jin BY, Kaji S, Koga J, Yamamoto Y, Fujisawa K, Hata I, Nakai A, Shigematsu Y, Mizunuma H, Taketo A, Mayumi M, Sudo M (Oct 1997). "Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiency". American Journal of Human Genetics. 61 (4): 852–61. doi:10.1086/514875. PMC 1715983. PMID 9382095.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.