FBXO2

F-box only protein 2 is a protein that in humans is encoded by the FBXO2 gene.

FBXO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UMH, 1UMI, 2E31, 2E32, 2E33, 2RJ2
Identifiers
Aliases	FBXO2, FBG1, FBX2, Fbs1, NFB42, OCP1, F-box protein 2
External IDs	OMIM: 607112; MGI: 2446216; HomoloGene: 8132; GeneCards: FBXO2; OMA:FBXO2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.22 Start 11,637,018 bp End 11,655,785 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 E2|4 78.68 cM Start 148,245,078 bp End 148,250,881 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amygdala C1 segment right frontal lobe anterior cingulate cortex caudate nucleus Brodmann area 9 putamen nucleus accumbens right hemisphere of cerebellum prefrontal cortex Top expressed in vestibular membrane of cochlear duct utricle vestibular sensory epithelium facial motor nucleus anterior horn of spinal cord optic nerve stria vascularis pontine nuclei medial vestibular nucleus cochlea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function amyloid-beta binding carbohydrate binding ubiquitin-protein transferase activity protein binding ubiquitin protein ligase activity Cellular component organelle membrane membrane SCF ubiquitin ligase complex intracellular membrane-bounded organelle dendritic spine endoplasmic reticulum cytosol cytoplasm Biological process ubiquitin-dependent protein catabolic process regulation of protein ubiquitination proteolysis SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination ubiquitin-dependent ERAD pathway glycoprotein catabolic process negative regulation of cell population proliferation protein polyubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26232 230904 Ensembl ENSG00000116661 ENSMUSG00000041556 UniProt Q9UK22 Q80UW2 RefSeq (mRNA) NM_012168 NM_176848 RefSeq (protein) NP_036300 NP_789818 Location (UCSC) Chr 1: 11.64 – 11.66 Mb Chr 4: 148.25 – 148.25 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.

Further reading

• Erhardt JA, Hynicka W, DiBenedetto A, et al. (1999). "A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest". J. Biol. Chem. 273 (52): 35222–7. doi:10.1074/jbc.273.52.35222. PMID 9857061.
• Yoshida Y, Chiba T, Tokunaga F, et al. (2002). "E3 ubiquitin ligase that recognizes sugar chains". Nature. 418 (6896): 438–42. Bibcode:2002Natur.418..438Y. doi:10.1038/nature00890. PMID 12140560. S2CID 4424996.
• Ilyin GP, Sérandour AL, Pigeon C, et al. (2003). "A new subfamily of structurally related human F-box proteins". Gene. 296 (1–2): 11–20. doi:10.1016/S0378-1119(02)00867-3. PMID 12383498.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Eom CY, Lehman IR (2003). "Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9803–7. Bibcode:2003PNAS..100.9803E. doi:10.1073/pnas.1733876100. PMC 187846. PMID 12904574.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.