Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene.[5][6]

FIBP
Identifiers
AliasesFIBP, FGFIBP-1, FGF1 intracellular binding protein, TROFAS
External IDsOMIM: 608296; MGI: 1926233; HomoloGene: 3106; GeneCards: FIBP; OMA:FIBP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004214
NM_198897

NM_001253832
NM_021438

RefSeq (protein)

NP_004205
NP_942600

NP_001240761
NP_067413

Location (UCSC)Chr 11: 65.88 – 65.89 MbChr 19: 5.51 – 5.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

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FIBP has been shown to interact with FGF1.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172500Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024911Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Kolpakova, E; Wiedłocha, A; Stenmark, H; Klingenberg, O; Faines, PO; Olsnes, S (15 November 1998). "Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor". Biochem. J. 336 (1): 213–22. doi:10.1042/bj3360213. PMC 1219860. PMID 9806903.
  6. ^ a b "Entrez Gene: FIBP fibroblast growth factor (acidic) intracellular binding protein". ncbi.nlm.nih.gov.

Further reading

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