FLII

This article is about the protein. For the enviromental index, see Forest Landscape Integrity Index.

Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.

FLII
Identifiers
Aliases	FLII, FLI, FLIL, Fli1, actin remodeling protein, FLII actin remodeling protein
External IDs	OMIM: 600362; MGI: 1342286; HomoloGene: 11092; GeneCards: FLII; OMA:FLII - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p11.2 Start 18,244,815 bp End 18,258,738 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B2|11 37.81 cM Start 60,604,949 bp End 60,618,089 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart muscle of thigh gastrocnemius muscle skeletal muscle tissue spleen mucosa of transverse colon pituitary gland anterior pituitary minor salivary glands right lobe of thyroid gland Top expressed in Ileal epithelium choroid plexus of fourth ventricle granulocyte cardiac muscle tissue of left ventricle lactiferous gland tracheobronchial tree internal carotid artery mesenteric lymph nodes right lung lobe muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding actin filament binding Cellular component cell junction cytoskeleton brush border nucleus focal adhesion nucleoplasm microtubule organizing center cytoplasm cytosol Biological process multicellular organism development actin filament severing regulation of transcription, DNA-templated actin cytoskeleton organization transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2314 14248 Ensembl ENSG00000177731 ENSG00000284571 ENSMUSG00000002812 UniProt Q13045 Q9JJ28 RefSeq (mRNA) NM_001256264 NM_001256265 NM_002018 NM_022009 NM_001302207 RefSeq (protein) NP_001243193 NP_001243194 NP_002009 NP_001289136 NP_071292 Location (UCSC) Chr 17: 18.24 – 18.26 Mb Chr 11: 60.6 – 60.62 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.

Interactions

FLII has been shown to interact with LRRFIP1 and TRAF interacting protein.

Further reading

• Campbell HD, Schimansky T, Claudianos C, et al. (1994). "The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11386–90. Bibcode:1993PNAS...9011386C. doi:10.1073/pnas.90.23.11386. PMC 47987. PMID 8248259.
• Campbell HD, Fountain S, Young IG, et al. (1997). "Genomic structure, evolution, and expression of human FLII, a gelsolin and leucine-rich-repeat family member: overlap with LLGL". Genomics. 42 (1): 46–54. doi:10.1006/geno.1997.4709. PMID 9177775.
• Liu YT, Yin HL (1998). "Identification of the binding partners for flightless I, A novel protein bridging the leucine-rich repeat and the gelsolin superfamilies". J. Biol. Chem. 273 (14): 7920–7. doi:10.1074/jbc.273.14.7920. PMID 9525888.
• Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I." Nucleic Acids Res. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.
• Fong KS, de Couet HG (1999). "Novel proteins interacting with the leucine-rich repeat domain of human flightless-I identified by the yeast two-hybrid system". Genomics. 58 (2): 146–57. doi:10.1006/geno.1999.5817. PMID 10366446.
• Davy DA, Campbell HD, Fountain S, et al. (2001). "The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases". J. Cell Sci. 114 (Pt 3): 549–62. doi:10.1242/jcs.114.3.549. PMID 11171324.
• Campbell HD, Fountain S, McLennan IS, et al. (2002). "Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development". Mol. Cell. Biol. 22 (10): 3518–26. doi:10.1128/MCB.22.10.3518-3526.2002. PMC 133791. PMID 11971982.
• Bi W, Yan J, Stankiewicz P, et al. (2002). "Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse". Genome Res. 12 (5): 713–28. doi:10.1101/gr.73702. PMC 186594. PMID 11997338.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Lee YH, Campbell HD, Stallcup MR (2004). "Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity". Mol. Cell. Biol. 24 (5): 2103–17. doi:10.1128/MCB.24.5.2103-2117.2004. PMC 350567. PMID 14966289.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang T, Chuang TH, Ronni T, et al. (2006). "Flightless I homolog negatively modulates the TLR pathway". J. Immunol. 176 (3): 1355–62. doi:10.4049/jimmunol.176.3.1355. PMID 16424162.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.