FOLR2

Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.

FOLR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4KMY, 4KMZ, 4KN0, 4KN1, 4KN2
Identifiers
Aliases	FOLR2, BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3, folate receptor beta, FRbeta, FOLR1
External IDs	OMIM: 136425; MGI: 95569; HomoloGene: 627; GeneCards: FOLR2; OMA:FOLR2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.4 Start 72,216,601 bp End 72,221,950 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E2 Start 101,489,195 bp End 101,506,401 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder right coronary artery synovial joint lymph node synovial membrane gonad pericardium decidua testicle rectum Top expressed in stroma of bone marrow lip ankle joint white adipose tissue esophagus muscle of thigh ankle mammary gland subcutaneous adipose tissue morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methotrexate binding folic acid binding folic acid receptor activity signaling receptor activity Cellular component cell surface anchored component of membrane anchored component of external side of plasma membrane membrane extracellular region plasma membrane Biological process inflammatory response receptor-mediated endocytosis positive regulation of cell population proliferation monocyte chemotaxis cellular response to folic acid folic acid metabolic process folic acid transport folate import across plasma membrane cell adhesion fusion of sperm to egg plasma membrane involved in single fertilization sperm-egg recognition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2350 14276 Ensembl ENSG00000165457 ENSMUSG00000032725 UniProt P14207 Q05685 RefSeq (mRNA) NM_000803 NM_001113534 NM_001113535 NM_001113536 NM_008035 NM_001303231 NM_001303239 RefSeq (protein) NP_000794 NP_001107006 NP_001107007 NP_001107008 NP_001290160 NP_001290168 NP_032061 Location (UCSC) Chr 11: 72.22 – 72.22 Mb Chr 7: 101.49 – 101.51 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.

Further reading

• Henderson GB (1990). "Folate-binding proteins". Annu. Rev. Nutr. 10: 319–35. doi:10.1146/annurev.nu.10.070190.001535. PMID 2166548.
• Ragoussis J, Senger G, Trowsdale J, Campbell IG (1992). "Genomic organization of the human folate receptor genes on chromosome 11q13". Genomics. 14 (2): 423–30. doi:10.1016/S0888-7543(05)80236-8. PMID 1330883.
• Freisheim JH, Price EM, Ratnam M (1990). "Folate coenzyme and antifolate transport proteins in normal and neoplastic cells". Adv. Enzyme Regul. 29: 13–26. doi:10.1016/0065-2571(89)90091-5. PMID 2561247.
• Ratnam M, Marquardt H, Duhring JL, Freisheim JH (1990). "Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA". Biochemistry. 28 (20): 8249–54. doi:10.1021/bi00446a042. PMID 2605182.
• Yan W, Ratnam M (1995). "Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal". Biochemistry. 34 (44): 14594–600. doi:10.1021/bi00044a039. PMID 7578066.
• Sadasivan E, Cedeno MM, Rothenberg SP (1994). "Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein". J. Biol. Chem. 269 (7): 4725–35. doi:10.1016/S0021-9258(17)37605-6. PMID 8106441.
• Shen F, Ross JF, Wang X, Ratnam M (1994). "Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity". Biochemistry. 33 (5): 1209–15. doi:10.1021/bi00171a021. PMID 8110752.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Page ST, Owen WC, Price K, Elwood PC (1993). "Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene". J. Mol. Biol. 229 (4): 1175–83. doi:10.1006/jmbi.1993.1116. PMID 8445646.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Wang J, Shen F, Yan W, et al. (1998). "Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion". Biochemistry. 36 (47): 14583–92. doi:10.1021/bi970845w. PMID 9398177.
• Nakashima-Matsushita N, Homma T, Yu S, et al. (1999). "Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis". Arthritis Rheum. 42 (8): 1609–16. doi:10.1002/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L. PMID 10446858.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hao H, Qi H, Ratnam M (2003). "Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites". Blood. 101 (11): 4551–60. doi:10.1182/blood-2002-10-3174. PMID 12543860.