FRS3

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.

FRS3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KUP, 2KUQ, 2YS5, 2YT2
Identifiers
Aliases	FRS3, FRS2-beta, FRS2B, FRS2beta, SNT-2, SNT2, fibroblast growth factor receptor substrate 3
External IDs	OMIM: 607744; MGI: 2135965; HomoloGene: 4845; GeneCards: FRS3; OMA:FRS3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.1 Start 41,770,176 bp End 41,786,542 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 C Start 47,999,955 bp End 48,015,211 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum anterior cingulate cortex prefrontal cortex right frontal lobe Brodmann area 9 hypothalamus amygdala right testis apex of heart left testis Top expressed in neural layer of retina spermatocyte central gray substance of midbrain yolk sac primary visual cortex cerebellar cortex superior frontal gyrus nucleus of stria terminalis paraventricular nucleus of hypothalamus seminiferous tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding fibroblast growth factor receptor binding identical protein binding Cellular component plasma membrane membrane intracellular anatomical structure Biological process fibroblast growth factor receptor signaling pathway signal transduction MAPK cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10817 107971 Ensembl ENSG00000137218 ENSMUSG00000023266 UniProt O43559 Q91WJ0 RefSeq (mRNA) NM_006653 NM_144939 RefSeq (protein) NP_006644 NP_659188 Location (UCSC) Chr 6: 41.77 – 41.79 Mb Chr 17: 48 – 48.02 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.

Further reading

• Lim YP, Low BC, Lim J, et al. (1999). "Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling". J. Biol. Chem. 274 (27): 19025–34. doi:10.1074/jbc.274.27.19025. PMID 10383403.
• Ong SH, Guy GR, Hadari YR, et al. (2000). "FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors". Mol. Cell. Biol. 20 (3): 979–89. doi:10.1128/MCB.20.3.979-989.2000. PMC 85215. PMID 10629055.
• Yamada M, Suzuki K, Mizutani M, et al. (2001). "Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system". J. Biochem. 130 (1): 157–65. doi:10.1093/oxfordjournals.jbchem.a002955. PMID 11432792.
• Yan KS, Kuti M, Yan S, et al. (2002). "FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors". J. Biol. Chem. 277 (19): 17088–94. doi:10.1074/jbc.M107963200. PMID 11877385.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ranzi V, Meakin SO, Miranda C, et al. (2003). "The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins". Endocrinology. 144 (3): 922–8. doi:10.1210/en.2002-221002. PMID 12586769.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Gotoh N, Laks S, Nakashima M, et al. (2004). "FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts". FEBS Lett. 564 (1–2): 14–8. doi:10.1016/S0014-5793(04)00287-X. PMID 15094036. S2CID 35571861.
• Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402. S2CID 6773754.
• Huang L, Gotoh N, Zhang S, et al. (2004). "SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation". Biochem. Biophys. Res. Commun. 324 (3): 1011–7. doi:10.1016/j.bbrc.2004.09.152. PMID 15485655.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Harada A, Katoh H, Negishi M (2005). "Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells". J. Biol. Chem. 280 (18): 18418–24. doi:10.1074/jbc.M411356200. PMID 15738000.
• Huang L, Watanabe M, Chikamori M, et al. (2006). "Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways". Oncogene. 25 (49): 6457–66. doi:10.1038/sj.onc.1209656. PMID 16702953. S2CID 23148856.