FSCN1

Fascin is a protein that in humans is encoded by the FSCN1 gene.

FSCN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DFC, 4GP0, 4GP3, 3P53, 4GOY, 4GOV, 3LLP
Identifiers
Aliases	FSCN1, FAN1, HSN, SNL, p55, fascin actin-bundling protein 1
External IDs	OMIM: 602689; MGI: 1352745; HomoloGene: 48164; GeneCards: FSCN1; OMA:FSCN1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p22.1 Start 5,592,816 bp End 5,606,655 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 G2|5 81.84 cM Start 142,946,098 bp End 142,958,940 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ganglionic eminence middle frontal gyrus frontal pole Brodmann area 10 C1 segment ventricular zone right frontal lobe putamen amygdala Top expressed in external carotid artery internal carotid artery abdominal wall Rostral migratory stream endothelial cell of lymphatic vessel condyle primitive streak endocardial cushion fossa mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity actin filament binding protein binding actin binding RNA binding cadherin binding Cellular component cytoplasm cell projection cell-cell junction filopodium ruffle myelin sheath stress fiber microvillus cell junction microspike cell projection membrane actin cytoskeleton podosome extracellular exosome cytoskeleton growth cone lamellipodium filamentous actin cytosol Biological process regulation of microvillus assembly establishment of apical/basal cell polarity regulation of actin cytoskeleton organization actin filament organization cell motility positive regulation of podosome assembly actin filament bundle assembly positive regulation of extracellular matrix disassembly cell-cell junction assembly microspike assembly cell population proliferation positive regulation of lamellipodium assembly cell migration positive regulation of filopodium assembly actin cytoskeleton organization anatomical structure morphogenesis establishment or maintenance of cell polarity cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6624 14086 Ensembl ENSG00000075618 ENSMUSG00000029581 UniProt Q16658 Q61553 RefSeq (mRNA) NM_003088 NM_007984 RefSeq (protein) NP_003079 NP_032010 Location (UCSC) Chr 7: 5.59 – 5.61 Mb Chr 5: 142.95 – 142.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

FSCN1 has been shown to interact with Low affinity nerve growth factor receptor and PKC alpha.

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Yamashiro-Matsumura S, Matsumura F (1985). "Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells". J. Biol. Chem. 260 (8): 5087–97. doi:10.1016/S0021-9258(18)89183-9. PMID 3886649.
• Mosialos G, Yamashiro S, Baughman RW, Matsudaira P, Vara L, Matsumura F, Kieff E, Birkenbach M (1994). "Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein". J. Virol. 68 (11): 7320–8. doi:10.1128/JVI.68.11.7320-7328.1994. PMC 237173. PMID 7933116.
• Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E (1996). "Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein". Am. J. Pathol. 148 (2): 593–600. PMC 1861678. PMID 8579121.
• Yamakita Y, Ono S, Matsumura F, Yamashiro S (1996). "Phosphorylation of human fascin inhibits its actin binding and bundling activities". J. Biol. Chem. 271 (21): 12632–8. doi:10.1074/jbc.271.21.12632. PMID 8647875.
• Lin XH, Grako KA, Burg MA, Stallcup WB (1997). "NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration". Mol. Biol. Cell. 7 (12): 1977–93. doi:10.1091/mbc.7.12.1977. PMC 276044. PMID 8970159.
• Ono S, Yamakita Y, Yamashiro S, Matsudaira PT, Gnarra JR, Obinata T, Matsumura F (1997). "Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin". J. Biol. Chem. 272 (4): 2527–33. doi:10.1074/jbc.272.4.2527. PMID 8999969.
• Pinkus GS, Pinkus JL, Langhoff E, Matsumura F, Yamashiro S, Mosialos G, Said JW (1997). "Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?". Am. J. Pathol. 150 (2): 543–62. PMC 1858289. PMID 9033270.
• Ross R, Ross XL, Schwing J, Längin T, Reske-Kunz AB (1998). "The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells". J. Immunol. 160 (8): 3776–82. doi:10.4049/jimmunol.160.8.3776. PMID 9558080.
• Sonderbye L, Meehan S, Palsson R, Ahsan N, Ladefoged J, Langhoff E (1998). "Immunohistochemical study of actin binding protein (p55) in the human kidney". Transplantation. 65 (7): 1004–8. doi:10.1097/00007890-199804150-00025. PMID 9565110.
• Kempf W, Levi E, Kamarashev J, Kutzner H, Pfeifer W, Petrogiannis-Haliotis T, Burg G, Kadin ME (2003). "Fascin expression in CD30-positive cutaneous lymphoproliferative disorders". J. Cutan. Pathol. 29 (5): 295–300. doi:10.1034/j.1600-0560.2002.290507.x. PMID 12100631. S2CID 31623792.
• Goncharuk VN, Ross JS, Carlson JA (2003). "Actin-binding protein fascin expression in skin neoplasia". J. Cutan. Pathol. 29 (7): 430–8. doi:10.1034/j.1600-0560.2002.290708.x. PMID 12139639. S2CID 26565797.
• Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, Sonzogni A, De Manzoni G, Terzi A, Durante E, Bresaola E, Pezzella F, Viale G (2003). "Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer". Br. J. Cancer. 88 (4): 537–47. doi:10.1038/sj.bjc.6600731. PMC 2377175. PMID 12592367.
• Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene. 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270. S2CID 13116876.
• Bros M, Ross XL, Pautz A, Reske-Kunz AB, Ross R (2003). "The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer". J. Immunol. 171 (4): 1825–34. doi:10.4049/jimmunol.171.4.1825. PMID 12902483.
• Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (2004). "Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112.
• Ishikawa R, Sakamoto T, Ando T, Higashi-Fujime S, Kohama K (2003). "Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro". J. Neurochem. 87 (3): 676–85. doi:10.1046/j.1471-4159.2003.02058.x. PMID 14535950. S2CID 927239.