FXYD6 (pronounced fix-id six), or FXYD domain-containing ion transport regulator 6, is a gene which is located at the 11q23.3 (chromosome 11 locus 23.3). The FXYD6 protein contains 95 amino acids, and can be found in all human tissues except blood.
| FXYD domain containing ion transport regulator 6 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FXYD6 | ||||||
| NCBI gene | 53826 | ||||||
| HGNC | 4030 | ||||||
| OMIM | 606683 | ||||||
| RefSeq | NM_022003 | ||||||
| UniProt | Q9H0Q3 | ||||||
| Other data | |||||||
| Locus | Chr. 11 q23.3 | ||||||
| |||||||
This gene belongs to the FXYD family of ion transport regulators [1]
Pathology
editAccording to recent research, mutations in the FXYD6 gene, or in sequences close by this gene, can predispose to the schizophrenia which is known to be strongly heritable.[2][3]
References
edit- ^ ATP1G1/PLM/MAT8 family in PFAM[permanent dead link]
- ^ Getting Crowded on Chromosome 11q22—Make Way for Phosphohippolin Archived April 30, 2007, at the Wayback Machine
- ^ Choudhury K, McQuillin A, Puri V, et al. (2007). "A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia". Am. J. Hum. Genet. 80 (4): 664–72. doi:10.1086/513475. PMC 1852702. PMID 17357072.