Ferm domain containing 4b

FERM domain containing 4B is a protein that in humans is encoded by the FRMD4B gene.

FRMD4B
Identifiers
Aliases	FRMD4B, 6030440G05Rik, GRSP1, FERM domain containing 4B
External IDs	OMIM: 617467; MGI: 2141794; HomoloGene: 14916; GeneCards: FRMD4B; OMA:FRMD4B - orthologs
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 D3 Start 97,263,828 bp End 97,594,502 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium Achilles tendon sural nerve corpus callosum oral cavity ganglionic eminence parietal pleura palpebral conjunctiva inferior ganglion of vagus nerve right lobe of thyroid gland Top expressed in ciliary body stroma of bone marrow vestibular membrane of cochlear duct retinal pigment epithelium conjunctival fornix vestibular sensory epithelium external carotid artery Rostral migratory stream Epithelium of choroid plexus iris More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 23150 232288 Ensembl n/a ENSMUSG00000030064 UniProt Q9Y2L6 Q920B0 RefSeq (mRNA) NM_015123 NM_145148 NM_001346637 NM_001346639 RefSeq (protein) NP_055938 NP_001333566 NP_001333568 NP_660130 Location (UCSC) n/a Chr 6: 97.26 – 97.59 Mb PubMed search
Wikidata
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Function

This gene encodes a GRP1-binding protein which contains a FERM protein interaction domain as well as two coiled coil domains. This protein may play a role as a scaffolding protein.

Further reading

• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• Cappola TP, Li M, He J, Ky B, Gilmore J, Qu L, Keating B, Reilly M, Kim CE, Glessner J, Frackelton E, Hakonarson H, Syed F, Hindes A, Matkovich SJ, Cresci S, Dorn GW (2010). "Common variants in HSPB7 and FRMD4B associated with advanced heart failure". Circ Cardiovasc Genet. 3 (2): 147–54. doi:10.1161/CIRCGENETICS.109.898395. PMC 2957840. PMID 20124441.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
• Matkovich SJ, Van Booven DJ, Cappola TP, Dorn GW (2010). "Association of an intronic, but not any exonic, FRMD4B sequence variant and heart failure". Clin Transl Sci. 3 (4): 134–9. doi:10.1111/j.1752-8062.2010.00220.x. PMC 2925316. PMID 20718813.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.