Ferric-chelate reductase (NADPH) (EC 1.16.1.9, ferric chelate reductase, iron chelate reductase, NADPH:Fe3+-EDTA reductase, NADPH-dependent ferric reductase, yqjH (gene)) is an enzyme with systematic name Fe(II):NADP+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
| Ferric-chelate reductase (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.16.1.9 | ||||||||
| CAS no. | 120720-17-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 2 Fe(II) + 2 apo-siderophore + NADP+ + H+ 2 Fe(III)-siderophore + NADPH
Ferric-chelate reductase contains FAD.
See also
editReferences
edit- ^ Bamford VA, Armour M, Mitchell SA, Cartron M, Andrews SC, Watson KA (September 2008). "Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative cytoplasmic ferri-siderophore reductase". Acta Crystallographica Section F. 64 (Pt 9): 792–6. doi:10.1107/S174430910802352X. PMC 2531270. PMID 18765906.
- ^ Wang S, Wu Y, Outten FW (January 2011). "Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli". Journal of Bacteriology. 193 (2): 563–74. doi:10.1128/JB.01062-10. PMC 3019823. PMID 21097627.
- ^ Miethke M, Hou J, Marahiel MA (December 2011). "The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli". Biochemistry. 50 (50): 10951–64. doi:10.1021/bi201517h. PMID 22098718.
External links
edit- Ferric-chelate+reductase+(NADPH) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
