Fibrinogen c domain containing 1

Fibrinogen C domain containing 1 (FIBCD1) is a protein that in humans is encoded by the FIBCD1 gene localized on chromosome 9q34.1 in close proximity to the genes encoding L- and M-ficolin. FIBCD1 is thought to have a role in both host defence and gut homeostasis.

FIBCD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4M7F, 4M7H
Identifiers
Aliases	FIBCD1, fibrinogen C domain containing 1
External IDs	OMIM: 613357; MGI: 2138953; HomoloGene: 122246; GeneCards: FIBCD1; OMA:FIBCD1 - orthologs
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 B Start 31,703,302 bp End 31,736,017 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle vena cava oocyte cerebellar vermis body of tongue hippocampus proper trabecular bone pons pericardium external globus pallidus Top expressed in hippocampus proper Region I of hippocampus proper subiculum primary visual cortex pharynx habenula dentate gyrus of hippocampal formation granule cell superior colliculus embryo superior frontal gyrus More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 84929 98970 Ensembl n/a ENSMUSG00000026841 UniProt Q8N539 A2AV25 RefSeq (mRNA) NM_032843 NM_001145106 NM_178887 RefSeq (protein) NP_001138578 NP_116232 NP_849218 Location (UCSC) n/a Chr 2: 31.7 – 31.74 Mb PubMed search
Wikidata
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Function

FIBCD1 is a type II trans-membrane endocytic receptor that is expressed apically on enterocytes and on airway epithelial cells (Schlosser et al., 2009). It is thought to mediate the endocytosis of bound ligands which are released to the surroundings after degradation, with FIBCD1 being recycled to the plasma membrane.

The homology between FIBCD1 and members of the ficolins, which are extensively characterised pattern-recognition molecules that have roles in the immune response, indicate FIBCD1 may have a role in host defence. Two potential phosphorylation sites in the cytoplasmic part of FIBCD1 suggest that FIBCD1 also may be a signaling protein (Schlosser et al., 2009).

Structure

FIBCD1 forms homo-tetramers in the plasma membrane, with each protein chain consisting of a short cytoplasmic tail, a trans-membrane helix, and an ectodomain containing a coiled-coil region, a polycationic region, and a C-terminal fibrinogen-like recognition domain, otherwise known as the FReD. (Shrive, et al., 2014)

Further reading

• Schlosser A, Thomsen T, Moeller JB, Nielsen O, Tornøe I, Mollenhauer J, Moestrup SK, Holmskov U (2009). "Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin". J. Immunol. 183 (6): 3800–9. doi:10.4049/jimmunol.0901526. PMID 19710473.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.