Filamin B, beta (FLNB ), also known as Filamin B, beta (truncated actin binding protein 278 homolog) , is a cytoplasmic protein which in humans is encoded by the FLNB gene .
FLNB Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DI8 , 2DI9 , 2DIA , 2DIB , 2DIC , 2DJ4 , 2DLG , 2DMB , 2DMC , 2E9I , 2E9J , 2EE6 , 2EE9 , 2EEA , 2EEB , 2EEC , 2EED , 2WA5 , 2WA6 , 2WA7 , 3FER , 4B7L
Identifiers Aliases FLNB External IDs OMIM : 603381 ; MGI : 2446089 ; HomoloGene : 37480 ; GeneCards : FLNB ; OMA :FLNB - orthologs Wikidata
FLNB regulates intracellular communication and signalling by cross-linking the protein actin to allow direct communication between the cell membrane and cytoskeletal network , to control and guide proper skeletal development.[ 5]
Mutations in the FLNB gene are involved in several lethal bone dysplasias , including boomerang dysplasia and atelosteogenesis type I .[ 6] [ 7] [ 8]
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